CYP2C9

CYP2C9
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1OG2, 1OG5, 1R9O, 4NZ2
Identifiers
Aliases	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9, cytochrome P450 family 2 subfamily C member 9, Cytochrome P450 2C9, P450-2C9
External IDs	OMIM: 601130; MGI: 1919553; HomoloGene: 133566; GeneCards: CYP2C9; OMA:CYP2C9 - orthologs
EC number	1.14.14.51
Gene location (Human)
Chr.	Chromosome 10 (human)
End	94,990,091 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	39,082,388 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; jejunal mucosa; ; pancreatic ductal cell; ; mucosa of ileum; ; duodenum; ; gallbladder; ; gingival epithelium; ; epithelium of esophagus; ; body of stomach; ; gastric mucosa;
	Top expressed in
	duodenum; ; jejunum; ; ileum; ; colon; ; stomach; ; esophagus; ; embryo; ; pancreas; ; islet of Langerhans; ; quadriceps femoris muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; arachidonic acid epoxygenase activity; metal ion binding; steroid hydroxylase activity; caffeine oxidase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;
Cellular component	organelle membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; cytoplasm;
Biological process	steroid metabolic process; lipid metabolism; cellular amide metabolic process; epoxygenase P450 pathway; monocarboxylic acid metabolic process; oxidative demethylation; omega-hydroxylase P450 pathway; monoterpenoid metabolic process; xenobiotic metabolic process; urea metabolic process; long-chain fatty acid biosynthetic process; organic acid metabolic process; estrogen metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1559
	72303
	ENSG00000138109
	ENSMUSG00000067231
	P11712
	n/a
	NM_000771
	NM_028191
	NP_000762
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by oxidation, of both xenobiotics, including drugs, and endogenous compounds, including fatty acids. In humans, the protein is encoded by the CYP2C9 gene.^[5]^[6] The gene is highly polymorphic, which affects the efficiency of the metabolism by the enzyme.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138109 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067231 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA (April 1991). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily". Biochemistry. 30 (13): 3247–3255. doi:10.1021/bi00227a012. PMID 2009263.
^ Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T (September 1994). "Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1". The Japanese Journal of Human Genetics. 39 (3): 337–343. doi:10.1007/BF01874052. PMID 7841444.
^ This article incorporates public domain material from "CYP2C9". National Center for Biotechnology Information, U.S. National Library of Medicine. National Center for Biotechnology Information. 29 March 2021. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen, and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. This article incorporates text from this source, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138109 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067231 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2009263-5] Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA (April 1991). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily". Biochemistry. 30 (13): 3247–3255. doi:10.1021/bi00227a012. PMID 2009263.

[pmid7841444-6] Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T (September 1994). "Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1". The Japanese Journal of Human Genetics. 39 (3): 337–343. doi:10.1007/BF01874052. PMID 7841444.

[ncbi1559-7] This article incorporates public domain material from "CYP2C9". National Center for Biotechnology Information, U.S. National Library of Medicine. National Center for Biotechnology Information. 29 March 2021. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen, and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. This article incorporates text from this source, which is in the public domain.

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