Carbimazole

Carbimazole
Clinical data
Trade names	Neo-Mercazole, Anti-Thyrox, etc.
AHFS/Drugs.com	International Drug Names
Pregnancy; category	AU: D;
Routes of; administration	By mouth
ATC code	H03BB01 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	85%
Elimination half-life	5.3h
Excretion	Kidney >90%
Identifiers
	IUPAC name ethyl 3-methyl-2-sulfanylidene-imidazole-1-carboxylate;
CAS Number	22232-54-8 ;
PubChem CID	31072;
DrugBank	DB00389 ;
ChemSpider	28829 ;
UNII	8KQ660G60G;
KEGG	D07616 ;
ChEBI	CHEBI:617099 ;
ChEMBL	ChEMBL508102 ;
CompTox Dashboard (EPA)	DTXSID9022736 ;
ECHA InfoCard	100.040.762
Chemical and physical data
Formula	C7H10N2O2S
Molar mass	186.23 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	122 to 125 °C (252 to 257 °F)
	SMILES S=C1N(\C=C/N1C(=O)OCC)C;
	InChI InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3 ; Key:CFOYWRHIYXMDOT-UHFFFAOYSA-N ;
	(verify)

Carbimazole (brand names Neo-Mercazole, Anti-Thyrox, etc.) is used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T₃ and T₄ (thyroxine).

It is on the World Health Organization's List of Essential Medicines.^[2]

^ "Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 12 May 2022. Retrieved 13 May 2022.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[1] "Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 12 May 2022. Retrieved 13 May 2022.

[WHO22nd-2] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[1]

[2]