Ceruloplasmin

CP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KCW, 2J5W, 4EJX, 4ENZ
Identifiers
Aliases	CP, CP-2, ceruloplasmin (ferroxidase), Ceruloplasmin, AB073614
External IDs	OMIM: 117700; MGI: 88476; HomoloGene: 75; GeneCards: CP; OMA:CP - orthologs
EC number	1.16.3.1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	149,221,829 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	20,063,309 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; palpebral conjunctiva; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; Epithelium of choroid plexus; ; ascending aorta; ; right coronary artery; ; tibial arteries;
	Top expressed in
	left lobe of liver; ; epithelium of lens; ; ciliary body; ; carotid body; ; vestibular membrane of cochlear duct; ; lactiferous gland; ; tibiofemoral joint; ; right lung lobe; ; left lung; ; gallbladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chaperone binding; metal ion binding; ferroxidase activity; oxidoreductase activity; copper ion binding; oxidoreductase activity, acting on metal ions;
Cellular component	blood microparticle; extracellular region; lysosomal membrane; extracellular exosome; extracellular space; endoplasmic reticulum lumen; plasma membrane;
Biological process	ion transport; copper ion transport; cellular iron ion homeostasis; post-translational protein modification; transport; iron ion transport; iron ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	1356
	12870
	ENSG00000047457
	ENSMUSG00000003617
	P00450
	Q61147
	NM_000096
	NM_001042611; NM_001276248; NM_001276250; NM_007752; NM_001374677
	NP_000087
	NP_001263177; NP_001263179; NP_031778; NP_001361606
	Wikidata
View/Edit Human	View/Edit Mouse

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene.^[5]^[6]^[7]

Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948.^[8] Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000047457 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003617 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takahashi N, Ortel TL, Putnam FW (Jan 1984). "Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule". Proceedings of the National Academy of Sciences of the United States of America. 81 (2): 390–4. Bibcode:1984PNAS...81..390T. doi:10.1073/pnas.81.2.390. PMC 344682. PMID 6582496.
^ Koschinsky ML, Funk WD, van Oost BA, MacGillivray RT (Jul 1986). "Complete cDNA sequence of human preceruloplasmin". Proceedings of the National Academy of Sciences of the United States of America. 83 (14): 5086–90. Bibcode:1986PNAS...83.5086K. doi:10.1073/pnas.83.14.5086. PMC 323895. PMID 2873574.
^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular Genetics. 13 (3): 285–92. doi:10.1007/BF01535211. PMID 3474786. S2CID 45686258.
^ Holmberg CG, Laurell CB (1948). "Investigations in serum copper. II. Isolation of the Copper containing protein, and a description of its properties". Acta Chem Scand. 2: 550–56. doi:10.3891/acta.chem.scand.02-0550 (inactive 15 July 2025).{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000047457 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003617 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6582496-5] Takahashi N, Ortel TL, Putnam FW (Jan 1984). "Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule". Proceedings of the National Academy of Sciences of the United States of America. 81 (2): 390–4. Bibcode:1984PNAS...81..390T. doi:10.1073/pnas.81.2.390. PMC 344682. PMID 6582496.

[pmid2873574-6] Koschinsky ML, Funk WD, van Oost BA, MacGillivray RT (Jul 1986). "Complete cDNA sequence of human preceruloplasmin". Proceedings of the National Academy of Sciences of the United States of America. 83 (14): 5086–90. Bibcode:1986PNAS...83.5086K. doi:10.1073/pnas.83.14.5086. PMC 323895. PMID 2873574.

[pmid3474786-7] Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular Genetics. 13 (3): 285–92. doi:10.1007/BF01535211. PMID 3474786. S2CID 45686258.

[8] Holmberg CG, Laurell CB (1948). "Investigations in serum copper. II. Isolation of the Copper containing protein, and a description of its properties". Acta Chem Scand. 2: 550–56. doi:10.3891/acta.chem.scand.02-0550 (inactive 15 July 2025).{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)

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