Cholecystokinin

CCK
Identifiers
Aliases	CCK, cholecystokinin
External IDs	OMIM: 118440; MGI: 88297; HomoloGene: 583; GeneCards: CCK; OMA:CCK - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	42,266,185 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	121,324,760 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 10; ; orbitofrontal cortex; ; middle temporal gyrus; ; dorsolateral prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; Brodmann area 9; ; superior frontal gyrus;
	Top expressed in
	primary motor cortex; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; CA3 field; ; lateral geniculate nucleus; ; Region I of hippocampus proper; ; medial dorsal nucleus; ; perirhinal cortex; ; superior frontal gyrus; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity; protein binding; neuropeptide hormone activity; peptide hormone receptor binding;
Cellular component	perikaryon; extracellular region; terminal bouton; soma; dendrite; axon hillock; axon initial segment; extracellular space; axon;
Biological process	regulation of sensory perception of pain; eating behavior; behavioral fear response; negative regulation of appetite; protein kinase C-activating G protein-coupled receptor signaling pathway; positive regulation of mitochondrial depolarization; positive regulation of glutamate secretion; positive regulation of cell population proliferation; positive regulation of protein oligomerization; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; signal transduction; release of cytochrome c from mitochondria; apoptotic process; neuron migration; axonogenesis; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; memory; visual learning; negative regulation of eating behavior; positive regulation of sensory perception of pain; negative regulation of behavioral fear response; positive regulation of behavioral fear response; digestion;
	Sources:Amigo / QuickGO
Orthologs
	885
	12424
	ENSG00000187094
	ENSMUSG00000032532
	P06307
	P09240
	NM_000729; NM_001174138
	NM_031161; NM_001284508
	NP_000720; NP_001167609
	NP_001271437; NP_112438
	Wikidata
View/Edit Human	View/Edit Mouse

Cholecystokinin (CCK or CCK-PZ; from Greek chole, "bile"; cysto, "sac"; kinin, "move"; hence, move the bile-sac (gallbladder)) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin, formerly called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum, the first segment of the small intestine. Its presence causes the release of pancreatic juice from the pancreas and bile from the gallbladder.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187094 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032532 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Johnson LR (2013). Gastrointestinal Physiology (Eighth ed.). Philadelphia: Elsevier/Mosby. ISBN 978-0-323-10085-4.
^ Bowen R (28 January 2001). "Cholecystokinin". Colorado State University. Archived from the original on 17 March 2016. Retrieved 6 November 2015.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187094 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032532 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Johnson_2014-5] Johnson LR (2013). Gastrointestinal Physiology (Eighth ed.). Philadelphia: Elsevier/Mosby. ISBN 978-0-323-10085-4.

[urlCholecystokinin-6] Bowen R (28 January 2001). "Cholecystokinin". Colorado State University. Archived from the original on 17 March 2016. Retrieved 6 November 2015.

[1]

[2]

[3]

[4]

[5]

[6]