Cinacalcet

Cinacalcet
Clinical data
Trade namesSensipar, Mimpara
AHFS/Drugs.comMonograph
MedlinePlusa605004
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)[2]
  • UK: POM (Prescription only)[3]
  • US: ℞-only[4]
  • EU: Rx-only[5]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability20 to 25%
increases if taken with food
Protein binding93 to 97%
MetabolismHepatic (CYP3A4-, CYP2D6- and CYP1A2-mediated)
Elimination half-life30 to 40 hours
ExcretionRenal (80%) and fecal (15%)
Identifiers
IUPAC name
  • (R)-N-[1-(1-naphthyl)ethyl]-3-
    [3-(trifluoromethyl)phenyl]propan-1-amine
CAS Number
PubChem CID
PubChem SID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.208.116
Chemical and physical data
FormulaC22H22F3N
Molar mass357.420 g·mol−1
3D model (JSmol)
SMILES
  • CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
InChI
  • InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1 Y
  • Key:VDHAWDNDOKGFTD-MRXNPFEDSA-N Y
 NY (what is this?)  (verify)

Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat primary hyperparathyroidism, tertiary hyperparathyroidism and parathyroid carcinoma.[4][6][5] Cinacalcet acts as a calcimimetic (i.e., it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues.

The most common side effects include nausea and vomiting.[5]

Cinacalcet was approved in the United States in March 2004,[4][7][8] and in the European Union in October 2004.[5][3] It was the first allosteric G protein-coupled receptor modulator to enter the pharmaceutical market.[9] In 2013, cinacalcet was the 76th most prescribed medicine in the United States.[10][11]

  1. ^ "Cinacalcet (Sensipar) Use During Pregnancy". Drugs.com. 19 July 2019. Retrieved 24 December 2019.
  2. ^ "Sensipar Tablets". NPS MedicineWise. 1 May 2018. Archived from the original on 7 December 2019. Retrieved 7 December 2019.
  3. ^ a b "Mimpara 30 mg Film-coated Tablets - Summary of Product Characteristics (SmPC)". electronic medicines compendium (emc). 8 July 2019. Archived from the original on 7 December 2019. Retrieved 7 December 2019.
  4. ^ a b c "Sensipar- cinacalcet hydrochloride tablet, coated". DailyMed. 5 December 2019. Retrieved 24 December 2019.
  5. ^ a b c d "Mimpara EPAR". European Medicines Agency (EMA). 22 August 2019. Retrieved 23 December 2019. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  6. ^ Cite error: The named reference FDA Pediatric was invoked but never defined (see the help page).
  7. ^ "Drug Approval Package: Sensipar (Cinacalcet HCI) NDA #021688". U.S. Food and Drug Administration (FDA). 7 December 2019. Archived from the original on 7 December 2019. Retrieved 7 December 2019. This article incorporates text from this source, which is in the public domain.
  8. ^ "Sensipar". U.S. Food and Drug Administration (FDA). Archived from the original on 7 December 2019. Retrieved 7 December 2019. This article incorporates text from this source, which is in the public domain.
  9. ^ Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Current Drug Targets. 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540.
  10. ^ "U.S. Pharmaceutical Statistics". Drugs.com. February 2014. Retrieved 13 July 2020.
  11. ^ "Sales Statistics for Sensipar Prescriptions". Drugs.com. 2 September 2020. Retrieved 8 September 2020.
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