Complement component 2

C2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I6S, 3ERB,%%s2ODQ
Identifiers
Aliases	C2, ARMD14, CO2, complement component 2, complement C2
External IDs	OMIM: 613927; MGI: 88226; HomoloGene: 45; GeneCards: C2; OMA:C2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,945,673 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,117,241 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; placenta; ; spleen; ; upper lobe of left lung; ; gallbladder; ; appendix; ; right lung; ; lymph node; ; duodenum;
	Top expressed in
	iris; ; decidua; ; adrenal gland; ; white adipose tissue; ; left lobe of liver; ; tunica adventitia of aorta; ; lumbar spinal ganglion; ; mesenteric lymph nodes; ; sciatic nerve; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; metal ion binding; serine-type endopeptidase activity; protein binding;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	complement activation; positive regulation of apoptotic cell clearance; regulation of complement activation; response to nutrient; proteolysis; complement activation, classical pathway; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	717
	12263
ENSG00000206372; ENSG00000235017; ENSG00000235696; ENSG00000226560; ENSG00000204364;
	ENSG00000166278; ENSG00000231543
	ENSMUSG00000024371
	P06681; Q5JP69
	P21180
NM_000063; NM_001145903; NM_001178063; NM_001282457; NM_001282458;
	NM_001282459
	NM_013484
NP_000054; NP_001139375; NP_001171534; NP_001269386; NP_001269387;
	NP_001269388; NP_000054.2
	NP_038512
	Wikidata
View/Edit Human	View/Edit Mouse

Complement C2 is a protein that in humans is encoded by the C2 gene.^[5] The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases.^[5]

The Complement system is generated to regulate self protection from infection. The overall Complement system is composed of protein groups that collaborate in destroying foreign invaders, which ultimately remove debris from cells and tissues. When the body detects a foreign invader, the body signals the Complement system and the Complement component 2 protein attaches to Complement system 4 resulting in an immune response. Complement component 2 protein is critical for regulating the body's immune response.

^ ^a ^b ^c ENSG00000235017, ENSG00000235696, ENSG00000226560, ENSG00000204364, ENSG00000166278, ENSG00000231543 GRCh38: Ensembl release 89: ENSG00000206372, ENSG00000235017, ENSG00000235696, ENSG00000226560, ENSG00000204364, ENSG00000166278, ENSG00000231543 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024371 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: C2 complement component 2".

[refGRCh38Ensembl-1] ENSG00000235017, ENSG00000235696, ENSG00000226560, ENSG00000204364, ENSG00000166278, ENSG00000231543 GRCh38: Ensembl release 89: ENSG00000206372, ENSG00000235017, ENSG00000235696, ENSG00000226560, ENSG00000204364, ENSG00000166278, ENSG00000231543 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024371 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: C2 complement component 2".

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