Complement component 7

C7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WCY
Identifiers
Aliases	C7, complement component 7, complement C7
External IDs	OMIM: 217070; MGI: 88235; HomoloGene: 489; GeneCards: C7; OMA:C7 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	40,984,643 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	5,093,222 bp
RNA expression pattern
	Top expressed in
	right ovary; ; superficial temporal artery; ; pericardium; ; right adrenal cortex; ; gastric mucosa; ; left adrenal gland; ; left adrenal cortex; ; gallbladder; ; right auricle of heart; ; right coronary artery;
	Top expressed in
	zone of skin; ; spermatid; ; esophagus; ; lung; ; testicle; ; spermatocyte; ; white adipose tissue; ; skeletal muscle tissue; ; adrenal gland; ; quadriceps femoris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	growth factor activity;
Cellular component	extracellular region; extracellular exosome; membrane attack complex;
Biological process	complement activation; cytolysis; regulation of complement activation; complement activation, alternative pathway; immune response; complement activation, classical pathway; immune system process; innate immune response; cellular sodium ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	730
	109828
	ENSG00000112936
	ENSMUSG00000079105
	P10643
	D3YXF5
	NM_000587
	NM_001243837
	NP_000578
	NP_001230766
	Wikidata
View/Edit Human	View/Edit Mouse

Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.

Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112936 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079105 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112936 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079105 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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