Cortistatin (neuropeptide)

CORT
Identifiers
Aliases	CORT, CST-14, CST-17, CST-29, cortistatin, SST2
External IDs	OMIM: 602784; MGI: 109538; HomoloGene: 997; GeneCards: CORT; OMA:CORT - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	10,451,998 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	149,211,220 bp
RNA expression pattern
	Top expressed in
	putamen; ; caudate nucleus; ; prefrontal cortex; ; nucleus accumbens; ; superior frontal gyrus; ; anterior cingulate cortex; ; gonad; ; temporal lobe; ; amygdala; ; Brodmann area 9;
	Top expressed in
	embryo; ; primary visual cortex; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; hippocampus proper; ; fetal liver hematopoietic progenitor cell; ; perirhinal cortex; ; tail of embryo; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide hormone activity; G protein-coupled receptor binding; hormone activity; chromatin binding; double-stranded DNA binding;
Cellular component	extracellular region; Fanconi anaemia nuclear complex; FANCM-MHF complex; extracellular space;
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; chemical synaptic transmission; mitotic recombination; resolution of meiotic recombination intermediates; interstrand cross-link repair; replication fork processing; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1325
	12854
	ENSG00000241563
	ENSMUSG00000028971
	O00230
	P56469
	NM_001302
	NM_007745
	NP_001293
	NP_031771
	Wikidata
View/Edit Human	View/Edit Mouse

Precortistatin is a protein that in humans is encoded by the CORT gene.^[5]^[6] The 105 amino acid residue human precortistatin in turn is cleaved into cortistatin-17 and cortistatin-29. Cortistatin-17 is the only active peptide derived from the precursor.^[5] Cortistatin (or more specifically cortistatin-17) is a neuropeptide that is expressed in inhibitory neurons of the cerebral cortex, and which has a strong structural similarity to somatostatin. Unlike somatostatin, when infused into the brain, it enhances slow-wave sleep. It binds to sites in the cortex, hippocampus and the amygdala.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000241563 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028971 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG (Sep 1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124. S2CID 24935564.
^ "Entrez Gene: CORT cortistatin".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000241563 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028971 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9205124-5] Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG (Sep 1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124. S2CID 24935564.

[entrez-6] "Entrez Gene: CORT cortistatin".

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