Daratumumab/hyaluronidase

Daratumumab/hyaluronidase
Combination of
DaratumumabCD38-directed cytolytic antibody
HyaluronidaseEndoglycosidase
Clinical data
Trade namesDarzalex Faspro
License data
Routes of
administration		Subcutaneous
ATC code
  • None
Legal status
Legal status
Identifiers
KEGG

Daratumumab/hyaluronidase, sold under the brand name Darzalex Faspro, is a fixed-dose combination medication for the treatment of adults with newly diagnosed or relapsed/refractory multiple myeloma.[2][1][3] It is a combination of daratumumab and hyaluronidase.[1] It is administered via subcutaneous injection.[1]

The most common adverse reaction using daratumumab/hyaluronidase as monotherapy is upper respiratory tracts infection.[1] The most common adverse reactions (≥20%) in people with amyloid light-chain amyloidosis who received daratumumab/hyaluronidase in combination with bortezomib, cyclophosphamide, and dexamethasone are upper respiratory tract infection, diarrhea, peripheral edema, constipation peripheral sensory neuropathy, fatigue, nausea, insomnia, dyspnea and cough.[4] The most common adverse reactions (≥20%) occurring in people treated with daratumumab/hyaluronidase, carfilzomib, and dexamethasone were upper respiratory tract infections, fatigue, insomnia, hypertension, diarrhea, cough, dyspnea, headache, pyrexia, nausea, and edema peripheral.[5]

  1. ^ a b c d e "Darzalex Faspro (daratumumab and hyaluronidase-fihj- human recombinant injection". DailyMed. Retrieved 15 January 2021.
  2. ^ Cite error: The named reference FDA PR was invoked but never defined (see the help page).
  3. ^ Sanchez L, Richter J, Cho HJ, Jagannath S, Madduri D, Parekh S, et al. (2021). "Subcutaneous daratumumab and hyaluronidase-fihj in newly diagnosed or relapsed/refractory multiple myeloma". Therapeutic Advances in Hematology. 12: 2040620720987075. doi:10.1177/2040620720987075. PMC 7841854. PMID 33613930.
  4. ^ Cite error: The named reference FDA 20200115 was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference FDA Darzalex Faspro/Kyprolis was invoked but never defined (see the help page).
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