Norfenfluramine

Norfenfluramine
Clinical data
Other names	3-Trifluoromethylamphetamine; 3-TFMA; Desethylfenfluramine; JP-92
Identifiers
	IUPAC name 1-[3-(trifluoromethyl)phenyl]propan-2-amine;
CAS Number	19036-73-8 ;
PubChem CID	15897;
IUPHAR/BPS	215;
ChemSpider	15108 ;
UNII	CLX07A6ZIY;
ChEBI	CHEBI:125411;
ChEMBL	ChEMBL1979333;
CompTox Dashboard (EPA)	DTXSID60904717 ;
Chemical and physical data
Formula	C10H12F3N
Molar mass	203.208 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c1cccc(c1)CC(N)C;
	InChI InChI=1S/C10H12F3N/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7H,5,14H2,1H3 ; Key:MLBHFBKZUPLWBD-UHFFFAOYSA-N ;
	(verify)

Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family and a major active metabolite of the appetite suppressants fenfluramine and benfluorex. The compound is a racemic mixture of two enantiomers with differing activities, dexnorfenfluramine and levonorfenfluramine.^[1]^[2]

^ Rothman RB, Clark RD, Partilla JS, Baumann MH (June 2003). "(+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters". The Journal of Pharmacology and Experimental Therapeutics. 305 (3): 1191–1199. doi:10.1124/jpet.103.049684. PMID 12649307. S2CID 21164342.
^ Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Blough B, et al. (June 2003). "3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro". Molecular Pharmacology. 63 (6): 1223–1229. doi:10.1124/mol.63.6.1223. PMID 12761331. S2CID 839426.