Enflurane

Enflurane
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	N01AB04 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances);
Pharmacokinetic data
Protein binding	97%
Identifiers
	IUPAC name (RS)-2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane;
CAS Number	13838-16-9 ;
PubChem CID	3226;
IUPHAR/BPS	7175;
DrugBank	DB00228 ;
ChemSpider	3113 ;
UNII	91I69L5AY5;
KEGG	D00543 ;
ChEBI	CHEBI:4792 ;
ChEMBL	ChEMBL1257 ;
CompTox Dashboard (EPA)	DTXSID1020562 ;
ECHA InfoCard	100.034.126
Chemical and physical data
Formula	C3H2ClF5O
Molar mass	184.49 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(Cl)C(F)(F)OC(F)F;
	InChI InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H ; Key:JPGQOUSTVILISH-UHFFFAOYSA-N ;
	(verify)

Enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s^[2] but is no longer in common use.^[3]

Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Niedermeyer E, Lopes da Silva FH (2005). Electroencephalography: Basic Principles, Clinical Applications, and Related Fields. Lippincott Williams & Wilkins. p. 1156. ISBN 978-0-7817-5126-1.
^ Hemmings Jr HC, Egan TD (2013). Pharmacology and Physiology for Anesthesia. doi:10.1016/C2009-0-41712-4. ISBN 9781437716795.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[NiedermeyerSilva2005-2] Niedermeyer E, Lopes da Silva FH (2005). Electroencephalography: Basic Principles, Clinical Applications, and Related Fields. Lippincott Williams & Wilkins. p. 1156. ISBN 978-0-7817-5126-1.

[3] Hemmings Jr HC, Egan TD (2013). Pharmacology and Physiology for Anesthesia. doi:10.1016/C2009-0-41712-4. ISBN 9781437716795.

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