Factor V

F5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S9C, 1CZS, 1CZV, 3P6Z, 3P70
Identifiers
Aliases	F5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V
External IDs	OMIM: 612309; MGI: 88382; HomoloGene: 104; GeneCards: F5; OMA:F5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	169,586,588 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	164,047,846 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; Epithelium of choroid plexus; ; pancreatic ductal cell; ; placenta; ; optic nerve; ; monocyte; ; olfactory zone of nasal mucosa; ; blood; ; gallbladder; ; granulocyte;
	Top expressed in
	Epithelium of choroid plexus; ; choroid plexus of fourth ventricle; ; left lobe of liver; ; ciliary body; ; lacrimal gland; ; blood; ; iris; ; granulocyte; ; tibiofemoral joint; ; parotid gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; copper ion binding;
Cellular component	platelet alpha granule; extracellular vesicle; endoplasmic reticulum lumen; membrane; plasma membrane; extracellular region; COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum-Golgi intermediate compartment membrane; platelet alpha granule lumen; Golgi apparatus; endoplasmic reticulum; Golgi membrane; extracellular space;
Biological process	hemostasis; platelet degranulation; blood coagulation; blood circulation; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating; response to vitamin K; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	2153
	14067
	ENSG00000198734
	ENSMUSG00000026579
	P12259
	O88783
	NM_000130
	NM_007976
	NP_000121
	NP_032002
	Wikidata
View/Edit Human	View/Edit Mouse

Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by F5 gene.^[5] In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor.^[5] Factor V deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198734 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026579 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "F5 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 9 May 2024.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198734 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026579 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Medline2024-5] "F5 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 9 May 2024.

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