Factor XI

F11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XX9, 1XXD, 1XXF, 1ZHM, 1ZHP, 1ZHR, 1ZJD, 1ZLR, 1ZMJ, 1ZML, 1ZMN, 1ZOM, 1ZPB, 1ZPC, 1ZPZ, 1ZRK, 1ZSJ, 1ZSK, 1ZSL, 1ZTJ, 1ZTK, 1ZTL, 2F83, 2FDA, 2J8J, 2J8L, 3BG8, 3SOR, 3SOS, 4CR5, 4CR9, 4CRA, 4CRB, 4CRC, 4CRD, 4CRE, 4CRF, 4CRG, 4NA7, 4NA8, 4TY6, 4TY7, 4WXI, 4X6M, 4X6N, 4X6O, 4X6P, 4Y8X, 4Y8Y, 4Y8Z, 4D7F, 5E2O, 5E2P, 4D76, 4D7G, 5EXL, 5I25, 5EXM, 5EOD, 5EXN, 5EOK
Identifiers
Aliases	F11, FXI, coagulation factor XI, PTA, factor XI
External IDs	OMIM: 264900; MGI: 99481; HomoloGene: 86654; GeneCards: F11; OMA:F11 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	186,289,681 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	45,715,068 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; jejunal mucosa; ; renal medulla; ; testicle; ; pancreatic epithelial cell; ; duodenum; ; pancreatic ductal cell; ; human kidney; ; gallbladder;
	Top expressed in
	left lobe of liver; ; right lobe of liver; ; fetal liver hematopoietic progenitor cell; ; sexually immature organism; ; seminiferous tubule; ; neural layer of retina; ; human fetus; ; atrioventricular valve; ; spermatid; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	serine-type aminopeptidase activity; peptidase activity; heparin binding; serine-type endopeptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; identical protein binding;
Cellular component	extracellular region; plasma membrane; extracellular exosome; membrane; extracellular space;
Biological process	hemostasis; blood coagulation, intrinsic pathway; plasminogen activation; regulation of blood coagulation; proteolysis; positive regulation of fibrinolysis; blood coagulation;
	Sources:Amigo / QuickGO
Orthologs
	2160
	109821
	ENSG00000088926
	ENSMUSG00000031645
	P03951
	Q91Y47
	NM_000128; NM_019559; NM_001354804
	NM_028066
	NP_000119; NP_001341733
	NP_082342
	Wikidata
View/Edit Human	View/Edit Mouse

Factor XI, or plasma thromboplastin antecedent, is the zymogen form of factor XIa, one of the enzymes involved in coagulation. Like many other coagulation factors, it is a serine protease. In humans, factor XI is encoded by F11 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088926 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031645 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fujikawa K, Chung DW, Hendrickson LE, Davie EW (May 1986). "Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein". Biochemistry. 25 (9): 2417–2424. doi:10.1021/bi00357a018. PMID 3636155.
^ Asakai R, Davie EW, Chung DW (Nov 1987). "Organization of the gene for human factor XI". Biochemistry. 26 (23): 7221–7228. doi:10.1021/bi00397a004. PMID 2827746.
^ Kato A, Asakai R, Davie EW, Aoki N (1989). "Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4". Cytogenetics and Cell Genetics. 52 (1–2): 77–78. doi:10.1159/000132844. PMID 2612218.
^ Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, et al. (May 1991). "A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates". American Journal of Human Genetics. 48 (5): 911–925. PMC 1683054. PMID 1673289.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000088926 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031645 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Fujikawa_1986-5] Fujikawa K, Chung DW, Hendrickson LE, Davie EW (May 1986). "Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein". Biochemistry. 25 (9): 2417–2424. doi:10.1021/bi00357a018. PMID 3636155.

[Asakai_1987-6] Asakai R, Davie EW, Chung DW (Nov 1987). "Organization of the gene for human factor XI". Biochemistry. 26 (23): 7221–7228. doi:10.1021/bi00397a004. PMID 2827746.

[Kato_1989-7] Kato A, Asakai R, Davie EW, Aoki N (1989). "Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4". Cytogenetics and Cell Genetics. 52 (1–2): 77–78. doi:10.1159/000132844. PMID 2612218.

[Buetow_1991-8] Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, et al. (May 1991). "A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates". American Journal of Human Genetics. 48 (5): 911–925. PMC 1683054. PMID 1673289.

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