Follistatin

FST
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HH2, 2B0U, 2P6A
Identifiers
Aliases	FST, FS, follistatin
External IDs	OMIM: 136470; MGI: 95586; HomoloGene: 7324; GeneCards: FST; OMA:FST - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	53,487,134 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	114,595,487 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; buccal mucosa cell; ; right lobe of liver; ; oocyte; ; secondary oocyte; ; mucosa of urinary bladder; ; Achilles tendon; ; pericardium; ; subcutaneous adipose tissue; ; gastric mucosa;
	Top expressed in
	cumulus cell; ; gastrula; ; primitive streak; ; endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; calvaria; ; ovary; ; decidua; ; epiblast; ; lumbar spinal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparan sulfate proteoglycan binding; protein binding; signal transducer activity; activin binding; activin receptor antagonist activity;
Cellular component	extracellular region;
Biological process	positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; hematopoietic progenitor cell differentiation; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10468
	14313
	ENSG00000134363
	ENSMUSG00000021765
	P19883
	P47931
	NM_006350; NM_013409
	NM_008046; NM_001301373; NM_001301375
	NP_006341; NP_037541
	NP_001288302; NP_001288304; NP_032072
	Wikidata
View/Edit Human	View/Edit Mouse

Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene.^[5]^[6] Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.^[6]

Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone.

An earlier name for the same protein was FSH-suppressing protein (FSP). At the time of its initial isolation from follicular fluid, it was found to inhibit the anterior pituitary's secretion of follicle-stimulating hormone (FSH).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134363 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021765 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ueno N, Ling N, Ying SY, Esch F, Shimasaki S, Guillemin R (December 1987). "Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America. 84 (23): 8282–8286. Bibcode:1987PNAS...84.8282U. doi:10.1073/pnas.84.23.8282. PMC 299526. PMID 3120188.
^ ^a ^b Tortoriello DV, Sidis Y, Holtzman DA, Holmes WE, Schneyer AL (August 2001). "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization". Endocrinology. 142 (8): 3426–3434. doi:10.1210/endo.142.8.8319. PMID 11459787.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134363 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021765 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3120188-5] Ueno N, Ling N, Ying SY, Esch F, Shimasaki S, Guillemin R (December 1987). "Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America. 84 (23): 8282–8286. Bibcode:1987PNAS...84.8282U. doi:10.1073/pnas.84.23.8282. PMC 299526. PMID 3120188.

[pmid11459787-6] Tortoriello DV, Sidis Y, Holtzman DA, Holmes WE, Schneyer AL (August 2001). "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization". Endocrinology. 142 (8): 3426–3434. doi:10.1210/endo.142.8.8319. PMID 11459787.

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