Growth hormone secretagogue receptor

GHSR
Identifiers
Aliases	GHSR, GHDP, growth hormone secretagogue receptor gene, growth hormone secretagogue receptor
External IDs	OMIM: 601898; MGI: 2441906; HomoloGene: 57161; GeneCards: GHSR; OMA:GHSR - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	172,448,456 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	27,432,159 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; islet of Langerhans; ; anterior pituitary; ; buccal mucosa cell; ; granulocyte; ; cecum; ; gonad; ; appendix; ; hypothalamus; ; blood;
	Top expressed in
	median eminence; ; arcuate nucleus; ; facial motor nucleus; ; dentate gyrus of hippocampal formation granule cell; ; mammillary body; ; ventral tegmental area; ; primary visual cortex; ; neural tube; ; medulla oblongata; ; spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone binding; signal transducer activity; peptide hormone binding; growth hormone-releasing hormone receptor activity; growth hormone secretagogue receptor activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; membrane; cell surface; neuron projection; membrane raft; plasma membrane; Schaffer collateral - CA1 synapse; postsynapse; glutamatergic synapse; integral component of synaptic membrane;
Biological process	negative regulation of interleukin-1 beta production; negative regulation of insulin secretion; regulation of synapse assembly; regulation of hindgut contraction; decidualization; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of fatty acid metabolic process; hormone-mediated signaling pathway; positive regulation of multicellular organism growth; cellular response to insulin stimulus; response to food; response to hormone; actin polymerization or depolymerization; negative regulation of inflammatory response; signal transduction; positive regulation of appetite; growth hormone secretion; adult feeding behavior; response to growth hormone; positive regulation of eating behavior; spermatogenesis; female pregnancy; learning or memory; negative regulation of norepinephrine secretion; negative regulation of appetite; response to follicle-stimulating hormone; response to estradiol; ghrelin secretion; regulation of transmission of nerve impulse; regulation of growth hormone secretion; cellular response to lipopolysaccharide; response to dexamethasone; negative regulation of locomotion involved in locomotory behavior; cellular response to thyroid hormone stimulus; positive regulation of sprouting angiogenesis; response to monosodium glutamate; regulation of gastric motility; positive regulation of vascular endothelial cell proliferation; cellular response to insulin-like growth factor stimulus; negative regulation of macrophage apoptotic process; positive regulation of growth; regulation of feeding behavior; positive regulation of small intestinal transit; positive regulation of small intestine smooth muscle contraction; G protein-coupled receptor signaling pathway; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; postsynaptic modulation of chemical synaptic transmission; regulation of postsynapse organization;
	Sources:Amigo / QuickGO
Orthologs
	2693
	208188
	ENSG00000121853
	ENSMUSG00000051136
	Q92847
	Q99P50
	NM_198407; NM_004122
	NM_177330
	NP_004113; NP_940799
	NP_796304
	Wikidata
View/Edit Human	View/Edit Mouse

Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone".^[5]^[6] The role of GHS-R is thought to be in regulating energy homeostasis and body weight.^[7] In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra.^[8] Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even in the heart.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121853 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051136 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, et al. (December 2005). "International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function". Pharmacological Reviews. 57 (4): 541–546. doi:10.1124/pr.57.4.1. PMID 16382107. S2CID 11254096.
^ Pradhan G, Samson SL, Sun Y (November 2013). "Ghrelin: much more than a hunger hormone". Current Opinion in Clinical Nutrition and Metabolic Care. 16 (6): 619–624. doi:10.1097/mco.0b013e328365b9be. PMC 4049314. PMID 24100676.
^ Pazos Y, Casanueva FF, Camiña JP (2008). "Basic aspects of ghrelin action". Ghrelin. Vitamins & Hormones. Vol. 77. pp. 89–119. doi:10.1016/S0083-6729(06)77005-4. ISBN 9780123736857. PMID 17983854.
^ Andrews ZB (January 2011). "The extra-hypothalamic actions of ghrelin on neuronal function". Trends in Neurosciences. 34 (1): 31–40. doi:10.1016/j.tins.2010.10.001. PMID 21035199. S2CID 42200775.
^ Yin Y, Li Y, Zhang W (March 2014). "The growth hormone secretagogue receptor: its intracellular signaling and regulation". International Journal of Molecular Sciences. 15 (3): 4837–4855. doi:10.3390/ijms15034837. PMC 3975427. PMID 24651458.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121853 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051136 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, et al. (December 2005). "International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function". Pharmacological Reviews. 57 (4): 541–546. doi:10.1124/pr.57.4.1. PMID 16382107. S2CID 11254096.

[Pradhan_2005-6] Pradhan G, Samson SL, Sun Y (November 2013). "Ghrelin: much more than a hunger hormone". Current Opinion in Clinical Nutrition and Metabolic Care. 16 (6): 619–624. doi:10.1097/mco.0b013e328365b9be. PMC 4049314. PMID 24100676.

[Pazos_2008-7] Pazos Y, Casanueva FF, Camiña JP (2008). "Basic aspects of ghrelin action". Ghrelin. Vitamins & Hormones. Vol. 77. pp. 89–119. doi:10.1016/S0083-6729(06)77005-4. ISBN 9780123736857. PMID 17983854.

[Andrews_2011-8] Andrews ZB (January 2011). "The extra-hypothalamic actions of ghrelin on neuronal function". Trends in Neurosciences. 34 (1): 31–40. doi:10.1016/j.tins.2010.10.001. PMID 21035199. S2CID 42200775.

[Yin_2014-9] Yin Y, Li Y, Zhang W (March 2014). "The growth hormone secretagogue receptor: its intracellular signaling and regulation". International Journal of Molecular Sciences. 15 (3): 4837–4855. doi:10.3390/ijms15034837. PMC 3975427. PMID 24651458.

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