Gonadotropin-releasing hormone

GNRH1
Identifiers
Aliases	GNRH1, GNRH, GRH, HH12, LHRH, LNRH, gonadotropin releasing hormone 1, Gonadotropin-Releasing Hormone
External IDs	OMIM: 152760; MGI: 95789; HomoloGene: 641; GeneCards: GNRH1; OMA:GNRH1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	25,424,654 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	67,986,888 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; testicle; ; cerebellar hemisphere; ; putamen; ; ascending aorta; ; Descending thoracic aorta; ; mucosa of transverse colon; ; right hemisphere of cerebellum; ; popliteal artery; ; tibial arteries;
	Top expressed in
	primary oocyte; ; bone marrow; ; embryonic cell; ; zygote; ; secondary oocyte; ; morula; ; neural layer of retina; ; granulocyte; ; thymus; ; preoptic area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity; gonadotropin hormone-releasing hormone activity; gonadotropin-releasing hormone receptor binding;
Cellular component	axon terminus; perikaryon; Golgi-associated vesicle; extracellular region; neurosecretory vesicle; dendrite; mitochondrion; neuron projection; cytoplasmic side of rough endoplasmic reticulum membrane; extracellular space;
Biological process	negative regulation of immature T cell proliferation; response to prolactin; negative regulation of neuron migration; response to potassium ion; response to organic cyclic compound; response to testosterone; estrous cycle; female pregnancy; cell-cell signaling; response to steroid hormone; ageing; response to peptide hormone; negative regulation of apoptotic process; male sex determination; multicellular organism development; response to prostaglandin E; response to lipopolysaccharide; response to corticosteroid; regulation of gene expression; ovulation cycle; response to ethanol; regulation of ovarian follicle development; signal transduction; negative regulation of cell population proliferation; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; reproduction;
	Sources:Amigo / QuickGO
Orthologs
	2796
	14714
	ENSG00000147437
	ENSMUSG00000015812
	P01148
	P13562
	NM_001083111; NM_000825
	NM_008145
	NP_000816; NP_001076580
	NP_032171
	Wikidata
View/Edit Human	View/Edit Mouse

Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. GnRH is inhibited by testosterone. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147437 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015812 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147437 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015812 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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