Granulocyte colony-stimulating factor

CSF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9Q, 1CD9, 1GNC, 1PGR, 1RHG
Identifiers
Aliases	CSF3, C17orf33, CSF3OS, GCSF, colony stimulating factor 3
External IDs	OMIM: 138970; MGI: 1339751; HomoloGene: 7677; GeneCards: CSF3; OMA:CSF3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,017,813 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,594,455 bp
RNA expression pattern
	Top expressed in
	testicle; ; olfactory zone of nasal mucosa; ; vena cava; ; muscle of thigh; ; gastrocnemius muscle; ; left uterine tube; ; cartilage tissue; ; upper lobe of left lung; ; mucosa of paranasal sinus; ; gonad;
	Top expressed in
	entorhinal cortex; ; embryo; ; CA3 field; ; lactiferous gland; ; cervix; ; endothelial cell of lymphatic vessel; ; medulla oblongata; ; primary motor cortex; ; blastocyst; ; integument;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; enzyme binding; growth factor activity; granulocyte colony-stimulating factor receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of protein kinase B signaling; positive regulation of actin filament polymerization; cellular response to cytokine stimulus; positive regulation of peptidyl-serine phosphorylation; multicellular organism development; granulocyte differentiation; immune response; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein binding; cellular response to lipopolysaccharide; positive regulation of actin cytoskeleton reorganization; positive regulation of transcription by RNA polymerase II; negative regulation of neuron death; positive regulation of myeloid cell differentiation; response to ethanol; positive regulation of cell population proliferation; neutrophil differentiation; macrophage differentiation; myeloid cell development; regulation of signaling receptor activity; cytokine-mediated signaling pathway; positive regulation of DNA-binding transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	1440
	12985
	ENSG00000108342
	ENSMUSG00000038067
	P09919
	P09920
	NM_000759; NM_001178147; NM_172219; NM_172220
	NM_009971
	NP_000750; NP_001171618; NP_757373; NP_757374
	NP_034101
	Wikidata
View/Edit Human	View/Edit Mouse

Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.^[5]^[6]

Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. The pharmaceutical analogs of naturally occurring G-CSF are called filgrastim and lenograstim.

G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108342 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038067 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Deotare U, Al-Dawsari G, Couban S, Lipton JH (September 2015). "G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept". Bone Marrow Transplantation. 50 (9): 1150–1156. doi:10.1038/bmt.2015.80. PMID 25915812. S2CID 20774089.
^ Tay J, Levesque JP, Winkler IG (February 2017). "Cellular players of hematopoietic stem cell mobilization in the bone marrow niche". International Journal of Hematology. 105 (2): 129–140. doi:10.1007/s12185-016-2162-4. PMID 27943116.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108342 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038067 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid25915812-5] Deotare U, Al-Dawsari G, Couban S, Lipton JH (September 2015). "G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept". Bone Marrow Transplantation. 50 (9): 1150–1156. doi:10.1038/bmt.2015.80. PMID 25915812. S2CID 20774089.

[pmid27943116-6] Tay J, Levesque JP, Winkler IG (February 2017). "Cellular players of hematopoietic stem cell mobilization in the bone marrow niche". International Journal of Hematology. 105 (2): 129–140. doi:10.1007/s12185-016-2162-4. PMID 27943116.

[1]

[2]

[3]

[4]

[5]

[6]