Haptocorrin

TCN1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4KKI, 4KKJ
Identifiers
Aliases	TCN1, HC, TC-1, TC1, TCI, transcobalamin 1
External IDs	OMIM: 189905; HomoloGene: 47985; GeneCards: TCN1; OMA:TCN1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	59,866,489 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; olfactory zone of nasal mucosa; ; trachea; ; parotid gland; ; gallbladder; ; bone marrow; ; bone marrow cell; ; nasal epithelium; ; trabecular bone; ; testicle;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	cobalamin binding;
Cellular component	extracellular region; extracellular space; specific granule lumen; tertiary granule lumen;
Biological process	cobalamin metabolic process; cobalt ion transport; ion transport; cobalamin transport; neutrophil degranulation; transport;
	Sources:Amigo / QuickGO
Orthologs
	6947
	n/a
	ENSG00000134827
	n/a
	P20061
	n/a
	NM_001062
	n/a
	NP_001053
	n/a
	Wikidata
View/Edit Human

Haptocorrin (HC) (also known as transcobalamin-1 (TC-1), or cobalophilin) is a transcobalamin^[3] glycoprotein.^[4] that in humans is encoded by the TCN1 gene.^[3] It is essential to protect the acid-sensitive vitamin B₁₂ from degradation while in the stomach. It is also present in the serum where it binds most circulating vitamin B₁₂, rendering it unavailable for uptake by cells (this is conjectured to be a circulating storage function).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134827 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: transcobalamin I (vitamin B₁₂ binding protein".
^ Cite error: The named reference isbn1-4051-3649-9 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134827 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: transcobalamin I (vitamin B₁₂ binding protein".

[isbn1-4051-3649-9-4] Cite error: The named reference isbn1-4051-3649-9 was invoked but never defined (see the help page).

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