Homeobox protein NANOG

NANOG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KT0
Identifiers
Aliases	NANOG, entrez:79923, Nanog, Nanog homeobox
External IDs	OMIM: 607937; MGI: 1919200; HomoloGene: 78027; GeneCards: NANOG; OMA:NANOG - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	7,799,146 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,691,592 bp
RNA expression pattern
	Top expressed in
	gonad; ; pericardium; ; cardia; ; thymus; ; mucosa of pharynx; ; ventral tegmental area; ; body of tongue; ; superior surface of tongue; ; trigeminal ganglion; ; synovial joint;
	Top expressed in
	blastocyst; ; epiblast; ; inner cell mass; ; morula; ; embryo; ; ureter; ; ectoderm; ; primordial germ cell; ; embryo; ; pharynx;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; sequence-specific DNA binding; protein binding; transcription corepressor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleolus; nucleus; nucleoplasm;
Biological process	regulation of gene expression; regulation of cell differentiation; multicellular organism development; cell differentiation; cell population proliferation; regulation of transcription, DNA-templated; somatic stem cell population maintenance; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; endodermal cell fate specification; negative regulation of nucleic acid-templated transcription; stem cell population maintenance; transcription by RNA polymerase II; cytokine-mediated signaling pathway; regulation of transcription by RNA polymerase II; positive regulation of stem cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	79923
	71950
	ENSG00000111704
	ENSMUSG00000012396
	Q9H9S0
	Q80Z64
	NM_001297698; NM_024865
	NM_028016; NM_001289828; NM_001289830; NM_001289831
	NP_001284627; NP_079141
	NP_001276757; NP_001276759; NP_001276760; NP_082292
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein NANOG (hNanog) is a transcriptional factor that helps embryonic stem cells (ESCs) maintain pluripotency by suppressing cell determination factors.^[5] hNanog is encoded in humans by the NANOG gene. Several types of cancer are associated with NANOG.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111704 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000012396 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Heurtier, V., Owens, N., Gonzalez, I. et al. The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells. Nat Commun 10, 1109 (2019). https://doi.org/10.1038/s41467-019-09041-z
^ Grubelnik G, Boštjančič E, Pavlič A, Kos M, Zidar N (March 2020). "NANOG expression in human development and cancerogenesis". Experimental Biology and Medicine. 245 (5): 456–464. doi:10.1177/1535370220905560. PMC 7082888. PMID 32041418.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111704 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000012396 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Heurtier, V., Owens, N., Gonzalez, I. et al. The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells. Nat Commun 10, 1109 (2019). https://doi.org/10.1038/s41467-019-09041-z

[EBM-6] Grubelnik G, Boštjančič E, Pavlič A, Kos M, Zidar N (March 2020). "NANOG expression in human development and cancerogenesis". Experimental Biology and Medicine. 245 (5): 456–464. doi:10.1177/1535370220905560. PMC 7082888. PMID 32041418.

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