Human β-globin locus

The human β-globin locus is a cluster of genes located on chromosome 11.[1] It is responsible for creating the β-chains found in hemoglobin. This cluster consists of 5 genes: ϵ, Gγ, Aγ, δ, and β genes, that respective order downstream.[2] These genes are controlled by a locus control region (LCR) and are differentially expressed throughout development.[2] Expression of these genes is regulated in embryonic erythropoiesis by many transcription factors, including KLF1, which is associated with the upregulation of adult hemoglobin in adult definitive erythrocytes, and KLF2, which is vital to the expression of embryonic hemoglobin.[3]

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  2. ^ a b Cite error: The named reference :15 was invoked but never defined (see the help page).
  3. ^ Alhashem, Yousef N.; Vinjamur, Divya S.; Basu, Mohua; Klingmüller, Ursula; Gaensler, Karin M. L.; Lloyd, Joyce A. (2011-07-15). "Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding". The Journal of Biological Chemistry. 286 (28): 24819–24827. doi:10.1074/jbc.M111.247536. ISSN 1083-351X. PMC 3137057. PMID 21610079.
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