Interleukin 17F

IL17F
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JPY, 3JVF
Identifiers
Aliases	IL17F, CANDF6, IL-17F, ML-1, ML1, interleukin 17F, IL17A
External IDs	OMIM: 606496; MGI: 2676631; HomoloGene: 17115; GeneCards: IL17F; OMA:IL17F - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	52,244,500 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	20,860,841 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; bone marrow cell; ; appendix; ; tonsil; ; left testis; ; lymph node; ; right testis; ; duodenum; ; urinary bladder;
	Top expressed in
	zygote; ; secondary oocyte; ; embryo; ; embryo; ; Rostral migratory stream; ; blastocyst; ; primary oocyte; ; proximal tubule; ; tail of embryo; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; protein homodimerization activity; cytokine binding; cytokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of angiogenesis; positive regulation of cytokine production involved in inflammatory response; cartilage development; positive regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; inflammatory response; regulation of signaling receptor activity; cytokine-mediated signaling pathway; interleukin-17-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	112744
	257630
	ENSG00000112116
	ENSMUSG00000041872
	Q96PD4
	Q7TNI7
	NM_052872; NM_172343
	NM_145856
	NP_443104
	NP_665855
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 17F (IL-17F) is signaling protein that is in human which is encoded by the IL17F gene and is considered a pro-inflammatory cytokine. This protein belongs to the interleukin 17 family and is mainly produced by the T helper 17 cells after their stimulation with interleukin 23. However, IL-17F can be also produced by a wide range of cell types, including innate immune cells and epithelial cells.^[5]^[6]^[7]^[8]

The IL17F gene is located on chromosome 6p12 and was discovered in 2001. This cytokine can be secreted as disulfide-linked homodimer or heterodimer.^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112116 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041872 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Linares-Pineda TM, Cañadas-Garre M, Sánchez-Pozo A, Calleja-Hernández MÁ (November 2016). "Gene polymorphisms as predictors of response to biological therapies in psoriasis patients". Pharmacological Research. 113 (Pt A): 71–80. doi:10.1016/j.phrs.2016.07.020. PMID 27524442.
^ Moseley TA, Haudenschild DR, Rose L, Reddi AH (April 2003). "Interleukin-17 family and IL-17 receptors". Cytokine & Growth Factor Reviews. 14 (2): 155–174. doi:10.1016/S1359-6101(03)00002-9. PMID 12651226.
^ Iwakura Y, Ishigame H, Saijo S, Nakae S (February 2011). "Functional specialization of interleukin-17 family members". Immunity. 34 (2): 149–162. doi:10.1016/j.immuni.2011.02.012. PMID 21349428.
^ McGeachy MJ, Cua DJ, Gaffen SL (April 2019). "The IL-17 Family of Cytokines in Health and Disease". Immunity. 50 (4): 892–906. doi:10.1016/j.immuni.2019.03.021. PMC 6474359. PMID 30995505.
^ Kawaguchi M, Kokubu F, Fujita J, Huang SK, Hizawa N (December 2009). "Role of interleukin-17F in asthma". Inflammation & Allergy - Drug Targets. 8 (5): 383–389. doi:10.2174/1871528110908050383. PMID 20025586.
^ Gorczynski RM (2020). "IL-17 Signaling in the Tumor Microenvironment". In Birbrair A (ed.). Tumor Microenvironment. Advances in Experimental Medicine and Biology. Vol. 1240. Cham: Springer International Publishing. pp. 47–58. doi:10.1007/978-3-030-38315-2_4. ISBN 978-3-030-38314-5. PMID 32060887. S2CID 211122697.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112116 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041872 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Linares-Pineda TM, Cañadas-Garre M, Sánchez-Pozo A, Calleja-Hernández MÁ (November 2016). "Gene polymorphisms as predictors of response to biological therapies in psoriasis patients". Pharmacological Research. 113 (Pt A): 71–80. doi:10.1016/j.phrs.2016.07.020. PMID 27524442.

[6] Moseley TA, Haudenschild DR, Rose L, Reddi AH (April 2003). "Interleukin-17 family and IL-17 receptors". Cytokine & Growth Factor Reviews. 14 (2): 155–174. doi:10.1016/S1359-6101(03)00002-9. PMID 12651226.

[:0-7] Iwakura Y, Ishigame H, Saijo S, Nakae S (February 2011). "Functional specialization of interleukin-17 family members". Immunity. 34 (2): 149–162. doi:10.1016/j.immuni.2011.02.012. PMID 21349428.

[8] McGeachy MJ, Cua DJ, Gaffen SL (April 2019). "The IL-17 Family of Cytokines in Health and Disease". Immunity. 50 (4): 892–906. doi:10.1016/j.immuni.2019.03.021. PMC 6474359. PMID 30995505.

[:1-9] Kawaguchi M, Kokubu F, Fujita J, Huang SK, Hizawa N (December 2009). "Role of interleukin-17F in asthma". Inflammation & Allergy - Drug Targets. 8 (5): 383–389. doi:10.2174/1871528110908050383. PMID 20025586.

[10] Gorczynski RM (2020). "IL-17 Signaling in the Tumor Microenvironment". In Birbrair A (ed.). Tumor Microenvironment. Advances in Experimental Medicine and Biology. Vol. 1240. Cham: Springer International Publishing. pp. 47–58. doi:10.1007/978-3-030-38315-2_4. ISBN 978-3-030-38314-5. PMID 32060887. S2CID 211122697.

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