Impact of alcohol on aging

The impact of alcohol on aging is multifaceted. Evidence shows that alcoholism or alcohol abuse can cause both accelerated (or premature) aging – in which symptoms of aging appear earlier than normal – and exaggerated aging, in which the symptoms appear at the appropriate time but in a more exaggerated form.[1] The effects of alcohol use disorder on the aging process include hypertension, cardiac dysrhythmia, cancers, gastrointestinal disorders, neurocognitive deficits, bone loss, and emotional disturbances especially depression.[2] Furthermore, chronic ethanol consumption can contribute to premature aging by depleting cellular NAD+, a key coenzyme vital for DNA repair and maintaining cellular health through proteins like sirtuins.[3][4][5][6]

  1. ^ Alcohol, Aging, and the Stress Response, RL Spencer and KE Hutchison, Alcohol Research & Health, Vol. 23, No. 4, 1999 Archived 2018-12-11 at the Wayback Machine ...alcohol-related overactivity of the HPA axis and the resulting elevated cortisol levels may contribute to premature or exaggerated aging in many people with a long history of alcohol abuse.
  2. ^ Stevenson JS (2005). "Alcohol use, misuse, abuse, and dependence in later adulthood". Annu Rev Nurs Res. 23: 245–80. doi:10.1891/0739-6686.23.1.245. PMID 16350768. S2CID 24586529.
  3. ^ Imai, S; Guarente, L (August 2014). "NAD+ and sirtuins in aging and disease". Trends in Cell Biology. 24 (8): 464–471. doi:10.1016/j.tcb.2014.04.002. PMC 4112140. PMID 24780232. Archived from the original on 2 May 2024.
  4. ^ Canto, C; Menzies, KJ; Auwerx, J (22 July 2015). "NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus". Cell Metabolism. 22 (1): 31–53. doi:10.1016/j.cmet.2015.05.023. PMC 4487780. PMID 26154028. Archived from the original on 2 May 2024.
  5. ^ Hu, M; Wang, F; Li, X (September 2016). "Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1862 (9): 1835–1846. doi:10.1016/j.bbadis.2016.06.023. PMC 5448157. PMID 27377119. Archived from the original on 2 May 2024.
  6. ^ "Is drinking alcohol part of a healthy lifestyle?".
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