Interleukin 10

IL10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24
Identifiers
Aliases	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10
External IDs	OMIM: 124092; MGI: 96537; HomoloGene: 478; GeneCards: IL10; OMA:IL10 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,774,541 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	130,952,711 bp
RNA expression pattern
	Top expressed in
	appendix; ; gallbladder; ; cartilage tissue; ; spleen; ; left uterine tube; ; lymph node; ; gastric mucosa; ; right adrenal cortex; ; left adrenal cortex; ; granulocyte;
	Top expressed in
	embryo; ; embryo; ; lumbar subsegment of spinal cord; ; stroma of bone marrow; ; entorhinal cortex; ; epiblast; ; lumbar spinal ganglion; ; thymus; ; tracheobronchial tree; ; stria vascularis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; growth factor activity; cytokine activity; interleukin-10 receptor binding; protein dimerization activity;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of chronic inflammatory response to antigenic stimulus; positive regulation of MHC class II biosynthetic process; negative regulation of endothelial cell apoptotic process; hemopoiesis; negative regulation of interferon-gamma production; regulation of sensory perception of pain; positive regulation of B cell apoptotic process; negative regulation of chemokine (C-C motif) ligand 5 production; response to inactivity; negative regulation of cytokine activity; negative regulation of interleukin-1 production; cellular response to hepatocyte growth factor stimulus; cellular response to estradiol stimulus; negative regulation of interleukin-6 production; ageing; positive regulation of DNA-binding transcription factor activity; negative regulation of apoptotic process; negative regulation of cytokine production involved in immune response; response to glucocorticoid; cytoplasmic sequestering of NF-kappaB; negative regulation of interleukin-18 production; negative regulation of MHC class II biosynthetic process; response to activity; response to organic substance; response to carbon monoxide; leukocyte chemotaxis; type 2 immune response; negative regulation of myeloid dendritic cell activation; response to insulin; negative regulation of interleukin-8 production; response to lipopolysaccharide; B cell proliferation; negative regulation of T cell proliferation; negative regulation of nitric oxide biosynthetic process; branching involved in labyrinthine layer morphogenesis; defense response to bacterium; regulation of complement-dependent cytotoxicity; immune response; regulation of gene expression; B cell differentiation; regulation of isotype switching; negative regulation of tumor necrosis factor production; negative regulation of membrane protein ectodomain proteolysis; inflammatory response; cellular response to lipopolysaccharide; negative regulation of B cell proliferation; negative regulation of inflammatory response; negative regulation of cytokine production; positive regulation of transcription by RNA polymerase II; negative regulation of interleukin-12 production; defense response to protozoan; negative regulation of sensory perception of pain; positive regulation of macrophage activation; liver regeneration; regulation of synapse organization; positive regulation of endothelial cell proliferation; negative regulation of cell population proliferation; negative regulation of heterotypic cell-cell adhesion; positive regulation of heterotypic cell-cell adhesion; positive regulation of cell cycle; negative regulation of mitotic cell cycle; endothelial cell apoptotic process; regulation of response to wounding; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell proliferation; interleukin-12-mediated signaling pathway; positive regulation of transcription, DNA-templated; negative regulation of autophagy; cytokine-mediated signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of hydrogen peroxide-induced neuron death; positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3586
	16153
	ENSG00000136634
	ENSMUSG00000016529
	P22301
	P18893
	NM_000572
	NM_010548
	NP_000563
	NP_034678
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene.^[5] IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins.^[6] Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and TYK2 respectively.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136634 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016529 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eskdale J, Kube D, Tesch H, Gallagher G (1997). "Mapping of the human IL10 gene and further characterization of the 5' flanking sequence". Immunogenetics. 46 (2): 120–128. doi:10.1007/s002510050250. PMID 9162098. S2CID 30126106.
^ ^a ^b Mosser DM, Zhang X (December 2008). "Interleukin-10: new perspectives on an old cytokine". Immunological Reviews. 226 (1): 205–218. doi:10.1111/j.1600-065X.2008.00706.x. PMC 2724982. PMID 19161426.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136634 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016529 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9162098-5] Eskdale J, Kube D, Tesch H, Gallagher G (1997). "Mapping of the human IL10 gene and further characterization of the 5' flanking sequence". Immunogenetics. 46 (2): 120–128. doi:10.1007/s002510050250. PMID 9162098. S2CID 30126106.

[Mosser_2008-6] Mosser DM, Zhang X (December 2008). "Interleukin-10: new perspectives on an old cytokine". Immunological Reviews. 226 (1): 205–218. doi:10.1111/j.1600-065X.2008.00706.x. PMC 2724982. PMID 19161426.

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