Interleukin 4

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Interleukin 4
Interleukin 4
	analysis of the solution structure of human interleukin 4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques
Identifiers
Symbol	IL4
Pfam	PF00727
Pfam clan	CL0053
InterPro	IPR002354
PROSITE	PDOC00655
SCOP2	2int / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

IL4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX
Identifiers
Aliases	IL4, Interleukin 4, IL-4
External IDs	MGI: 96556; HomoloGene: 491; GeneCards: IL4; OMA:IL4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,018,370 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,509,496 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; testicle; ; gonad; ; right uterine tube; ; monocyte; ; anterior pituitary; ; right coronary artery; ; olfactory zone of nasal mucosa; ; bone marrow cell;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; spermatocyte; ; primary visual cortex; ; lens; ; embryo; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	interleukin-4 receptor binding; protein binding; growth factor activity; cytokine receptor binding; cytokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of T cell differentiation; dendritic cell differentiation; negative regulation of endothelial cell apoptotic process; negative regulation of complement-dependent cytotoxicity; regulation of phosphorylation; negative regulation of apoptotic process; myeloid dendritic cell differentiation; type 2 immune response; B cell activation; positive regulation of interleukin-13 production; immune response; B cell differentiation; T-helper 2 cell cytokine production; regulation of isotype switching; negative regulation of transcription, DNA-templated; negative regulation of epithelial cell migration; regulation of signaling receptor activity; cholesterol metabolic process; positive regulation of B cell proliferation; positive regulation of T cell proliferation; T cell activation; positive regulation of MHC class II biosynthetic process; negative regulation of osteoclast differentiation; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; regulation of immune response; cytokine-mediated signaling pathway; positive regulation of gene expression; positive regulation of macroautophagy; positive regulation of tyrosine phosphorylation of STAT protein; activation of Janus kinase activity; positive regulation of receptor-mediated endocytosis; positive regulation of cold-induced thermogenesis; negative regulation of neuroinflammatory response; positive regulation of amyloid-beta clearance; neuroinflammatory response; positive regulation of cellular respiration; positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	3565
	16189
	ENSG00000113520
	ENSMUSG00000000869
	P05112
	P07750
	NM_000589.4
	NM_021283
	NP_000580; NP_758858; NP_001341919
	NP_067258
	Wikidata
View/Edit Human	View/Edit Mouse

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T_h0 cells) to T_h2 cells. Upon activation by IL-4, T_h2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, T_h2 cells, eosinophils and basophils.^[4] It is closely related and has functions similar to IL-13.

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000869 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gadani SP, Cronk JC, Norris GT, Kipnis J (November 2012). "IL-4 in the brain: a cytokine to remember". Journal of Immunology. 189 (9): 4213–4219. doi:10.4049/jimmunol.1202246. PMC 3481177. PMID 23087426.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000000869 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Gadani SP, Cronk JC, Norris GT, Kipnis J (November 2012). "IL-4 in the brain: a cytokine to remember". Journal of Immunology. 189 (9): 4213–4219. doi:10.4049/jimmunol.1202246. PMC 3481177. PMID 23087426.

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