Kininogen 1

KNG1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1NY2, 2WOK, 4ASQ, 4ASR, 4ECB, 4ECC, 5I25
Identifiers
Aliases	KNG1, BDK, BK, KNG, Kininogen 1, HMWK, HAE6, HK
External IDs	OMIM: 612358; MGI: 3027157; HomoloGene: 88343; GeneCards: KNG1; OMA:KNG1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	186,744,410 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	22,848,232 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; liver; ; right lobe of liver; ; kidney tubule; ; metanephric glomerulus; ; human kidney; ; testicle; ; pancreatic ductal cell; ; rectum; ; prefrontal cortex;
	Top expressed in
	right kidney; ; human kidney; ; renal cortex; ; proximal tubule; ; liver; ; bone marrow; ; embryo; ; morula; ; placenta; ; esophagus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; heparin binding; zinc ion binding; protein binding; signaling receptor binding; cysteine-type endopeptidase inhibitor activity;
Cellular component	blood microparticle; plasma membrane; extracellular exosome; platelet alpha granule lumen; extracellular space; endoplasmic reticulum lumen; extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	hemostasis; blood coagulation, intrinsic pathway; negative regulation of proteolysis; negative regulation of cell adhesion; negative regulation of peptidase activity; negative regulation of blood coagulation; positive regulation of cytosolic calcium ion concentration; platelet degranulation; vasodilation; positive regulation of apoptotic process; inflammatory response; blood coagulation; negative regulation of endopeptidase activity; post-translational protein modification; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3827
	385643
	ENSG00000113889
	ENSMUSG00000060459
	P01042
	n/a
	NM_001166451; NM_000893; NM_001102416
	NM_001102409; NM_001102410; NM_201375
	NP_000884; NP_001095886; NP_001159923
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein^[5] that in humans is encoded by the KNG1 gene.^[6]^[7] Kininogen-1 is the precursor protein to high-molecular-weight kininogen (HMWK), low-molecular-weight kininogen (LMWK), and bradykinin.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113889 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060459 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b UniProt: P01042
^ "Entrez Gene: kininogen 1".
^ KNG1 GeneCard for KNG1

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113889 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060459 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-5] UniProt: P01042

[entrez-6] "Entrez Gene: kininogen 1".

[7] KNG1 GeneCard for KNG1

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