Kleihauer–Betke test

Not to be confused with the Kirby–Bauer test, which is also often called a "KB test".
Kleihauer–Betke test
Kleihauer test, showing fetal red blood cells in rose-pink color, while adult red blood cells are only seen as "ghosts"
Purposemeasures fetal hemoglobin transfer
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The Kleihauer–Betke ("KB") test, Kleihauer–Betke ("KB") stain, Kleihauer test or acid elution test is a blood test used to measure the amount of fetal hemoglobin transferred from a fetus to a mother's bloodstream.[1] It is usually performed on Rh-negative mothers to determine the required dose of Rho(D) immune globulin (RhIg) to inhibit formation of Rh antibodies in the mother and prevent Rh disease in future Rh-positive children.[2] It is named after Enno Kleihauer and Klaus Betke who described it in 1957.

  1. ^ Katiyar R, Kriplani A, Agarwal N, Bhatla N, Kabra M (2007). "Detection of fetomaternal hemorrhage following chorionic villus sampling by Kleihauer–Betke test and rise in maternal serum alpha feto protein". Prenat. Diagn. 27 (2): 139–42. doi:10.1002/pd.1632. PMID 17191260. S2CID 36617092.
  2. ^ Kim YA, Makar RS (April 2012). "Detection of fetomaternal hemorrhage". American Journal of Hematology. 87 (4): 417–23. doi:10.1002/ajh.22255. PMID 22231030. S2CID 43712143.
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