Levomethamphetamine
| Clinical data | |
|---|---|
| Trade names | Vicks VapoInhaler, Everclear Inhaler, others |
| Other names | l-methamphetamine; (-)-methamphetamine; (R)-methamphetamine; (R)-(-)-methamphetamine; l-desoxyephedrine; levodesoxyephedrine |
| Routes of administration | Medical: Intranasal Recreational: By mouth, intravenous, insufflation, inhalation, suppository |
| Drug class | Norepinephrine releasing agent; Decongestant |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | Oral: ~100%[2][3] |
| Metabolism | Liver (CYP2D6)[5][6] |
| Metabolites | Levoamphetamine[2][4][3] |
| Elimination half-life | 10–15 hours[2][4][3] |
| Excretion | Urine (41–49% unchanged, 2–3% as levoamphetamine)[2][4][3] |
| Identifiers | |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.046.974 |
| Chemical and physical data | |
| Formula | C10H15N |
| Molar mass | 149.237 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Levorotatory enantiomer |
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Levomethamphetamine[a] (INN: levmetamfetamine) is an optical isomer of methamphetamine primarily used as a topical nasal decongestant.[2] Levomethamphetamine is used to treat nasal congestion from allergies and the common cold.[7] It was first used medically as decongestant beginning in 1958 and has been used for such purposes, primarily in the United States, since then.[8]
- ^ Anvisa (28 May 2024). "RDC Nº 877 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 877 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União. Archived from the original on 25 September 2024. Retrieved 25 September 2024.
- ^ a b c d e Barkholtz HM, Hadzima R, Miles A (July 2023). "Pharmacology of R-(-)-Methamphetamine in Humans: A Systematic Review of the Literature". ACS Pharmacol Transl Sci. 6 (7): 914–924. doi:10.1021/acsptsci.3c00019. PMC 10353062. PMID 37470013.
- ^ a b c d Cite error: The named reference
LiLopezGalloway2010was invoked but never defined (see the help page). - ^ a b c Cite error: The named reference
MendelsonUemuraHarris2006was invoked but never defined (see the help page). - ^ Cite error: The named reference
KraemerMaurer2002was invoked but never defined (see the help page). - ^ Cite error: The named reference
ScheininAnttilaDahl1998was invoked but never defined (see the help page). - ^ "Cold, Cough, Allergy, Bronchodilator, and Antiasthmatic Drug Products for Over-the-Counter Human Use". FDA. 7 June 2023. Archived from the original on 6 July 2023.
- ^ Cite error: The named reference
WessonSmithMorgan1986was invoked but never defined (see the help page).
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