Loratadine
| Clinical data | |
|---|---|
| Trade names | Claritin, Claratyne, Clarityn, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a697038 |
| License data |
|
| Pregnancy category |
|
| Routes of administration | By mouth |
| Drug class | Second-generation antihistamine |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | almost 100% |
| Protein binding | 97–99% |
| Metabolism | Liver (CYP2D6- and 3A4-mediated) |
| Elimination half-life | 8 hours, active metabolite desloratadine 27 hours |
| Excretion | 40% as conjugated metabolites into urine Similar amount into the feces |
| Identifiers | |
IUPAC name
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.120.122 |
| Chemical and physical data | |
| Formula | C22H23ClN2O2 |
| Molar mass | 382.89 g·mol−1 |
| 3D model (JSmol) | |
SMILES
| |
InChI
| |
| (what is this?) (verify) | |
Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies.[4] This includes allergic rhinitis (hay fever) and hives.[4] It is also available in drug combinations such as loratadine/pseudoephedrine, in which it is combined with pseudoephedrine, a nasal decongestant.[4] It is taken orally.[4]
Common side effects include sleepiness, dry mouth, and headache.[4] Serious side effects are rare and include allergic reactions, seizures, and liver problems.[5] Use during pregnancy appears to be safe but has not been well studied.[1] It is not recommended in children less than two years old.[5] It is in the second-generation antihistamine family of medications.[4]
Loratadine was patented in 1980 and came to market in 1988.[6] It is on the World Health Organization's List of Essential Medicines.[7] Loratadine is available as a generic medication.[4][8] In the United States, it is available over the counter.[4] In 2022, it was the 72nd most commonly prescribed medication in the United States, with more than 9 million prescriptions.[9][10] In 2022, the combination with pseudoephedrine was the 289th most commonly prescribed medication in the United States, with more than 500,000 prescriptions.[9][11]
- ^ a b "Loratadine Use During Pregnancy". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 13 December 2016.
- ^ "Claritin Allergy Product information". Health Canada. 25 April 2012. Retrieved 7 June 2022.
- ^ "Clarityn Allergy 10mg Tablets (P & GSL) - Patient Information Leaflet (PIL)". (emc). 30 August 2019. Archived from the original on 10 April 2020. Retrieved 10 April 2020.
- ^ a b c d e f g h "Loratadine". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
- ^ a b "Clarityn Allergy 10mg Tablets (P) - Summary of Product Characteristics (SmPC) - (eMC)". www.medicines.org.uk. 7 October 2015. Archived from the original on 20 December 2016. Retrieved 13 December 2016.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Archived from the original on 20 February 2020. Retrieved 6 March 2023.
- ^ a b "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
- ^ "Loratadine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
- ^ "Loratadine; Pseudoephedrine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.