Mannan-binding lectin

MBL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HUP
Identifiers
Aliases	MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD, mannose binding lectin 2
External IDs	OMIM: 154545; MGI: 96924; HomoloGene: 110436; GeneCards: MBL2; OMA:MBL2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	52,772,784 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	30,217,087 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; buccal mucosa cell; ; kidney; ; haematopoietic system; ; atrium; ; right atrium; ; spleen; ; right auricle of heart; ; stomach;
	Top expressed in
	left lobe of liver; ; primary oocyte; ; secondary oocyte; ; zygote; ; yolk sac; ; gallbladder; ; plantaris muscle; ; extensor digitorum longus muscle; ; morula; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; calcium-dependent protein binding; protein binding; mannose binding; signaling receptor binding; carbohydrate binding; serine-type endopeptidase activity;
Cellular component	collagen; extracellular region; cell surface; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	complement activation, lectin pathway; positive regulation of phagocytosis; killing by host of symbiont cells; negative regulation of viral process; immune system process; complement activation; response to oxidative stress; acute-phase response; defense response to bacterium; complement activation, classical pathway; opsonization; defense response to Gram-positive bacterium; innate immune response; proteolysis; growth plate cartilage chondrocyte morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4153
	17195
	ENSG00000165471
	ENSMUSG00000024863
	P11226
	P41317
	NM_000242; NM_001378373; NM_001378374
	NM_010776; NM_001365058
	NP_000233; NP_001365302; NP_001365303
	NP_034906; NP_001351987
	Wikidata
View/Edit Human	View/Edit Mouse

Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity^[5]^[6] as an opsonin and via the lectin pathway.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165471 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024863 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fraser IP, Koziel H, Ezekowitz RA (Oct 1998). "The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity". Seminars in Immunology. 10 (5): 363–372. doi:10.1006/smim.1998.0141. PMID 9799711.
^ Worthley DL, Bardy PG, Mullighan CG (Sep 2005). "Mannose-binding lectin: biology and clinical implications". Internal Medicine Journal. 35 (9): 548–555. doi:10.1111/j.1445-5994.2005.00908.x. PMID 16105157. S2CID 40041919.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165471 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024863 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Fraser IP, Koziel H, Ezekowitz RA (Oct 1998). "The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity". Seminars in Immunology. 10 (5): 363–372. doi:10.1006/smim.1998.0141. PMID 9799711.

[6] Worthley DL, Bardy PG, Mullighan CG (Sep 2005). "Mannose-binding lectin: biology and clinical implications". Internal Medicine Journal. 35 (9): 548–555. doi:10.1111/j.1445-5994.2005.00908.x. PMID 16105157. S2CID 40041919.

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