Milatuzumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | CD74 |
| Clinical data | |
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| Identifiers | |
| CAS Number | |
| ChemSpider |
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| Chemical and physical data | |
| Formula | C6518H10066N1758O2020S40 |
| Molar mass | 146658.91 g·mol−1 |
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Milatuzumab (or hLL1) is an anti-CD74[1] humanized monoclonal antibody for the treatment of multiple myeloma non-Hodgkin's lymphoma and chronic lymphocytic leukemia.[2][3]
The drug is the first anti-CD74 antibody that has entered into human testing and is currently being studied for the treatment of multiple myeloma. Milatuzumab has received orphan drug designation from the Food and Drug Administration in the United States for the treatment of multiple myeloma and chronic lymphocytic leukemia.
Milatuzumab was developed by Immunomedics, Inc, (Morris Plains NJ USA).
- ^ Stein R, Mattes MJ, Cardillo TM, Hansen HJ, Chang CH, Burton J, et al. (September 2007). "CD74: a new candidate target for the immunotherapy of B-cell neoplasms". Clinical Cancer Research. 13 (18 Pt 2): 5556s – 5563s. doi:10.1158/1078-0432.CCR-07-1167. PMID 17875789. S2CID 23818626.
- ^ Alinari L, Yu B, Christian BA, Yan F, Shin J, Lapalombella R, et al. (April 2011). "Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma". Blood. 117 (17): 4530–4541. doi:10.1182/blood-2010-08-303354. PMC 3099572. PMID 21228331.
- ^ Berkova Z, Tao RH, Samaniego F (January 2010). "Milatuzumab - a promising new immunotherapeutic agent". Expert Opinion on Investigational Drugs. 19 (1): 141–9. doi:10.1517/13543780903463854. PMID 19968579. S2CID 207475327.