Monoamine oxidase A

MAOA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Z5Y, 2BXR, 2BXS, 2Z5X
Identifiers
Aliases	MAOA, MAO-A, monoamine oxidase A, BRNRS
External IDs	OMIM: 309850; MGI: 96915; HomoloGene: 203; GeneCards: MAOA; OMA:MAOA - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	43,746,817 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	16,554,057 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of colon; ; mucosa of sigmoid colon; ; right lung; ; jejunal mucosa; ; duodenum; ; rectum; ; parotid gland; ; gastric mucosa; ; mucosa of transverse colon;
	Top expressed in
	left colon; ; superior cervical ganglion; ; jejunum; ; duodenum; ; intestinal villus; ; Ileal epithelium; ; stroma of bone marrow; ; endothelial cell of lymphatic vessel; ; crypt of lieberkuhn of small intestine; ; Paneth cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	primary amine oxidase activity; oxidoreductase activity;
Cellular component	integral component of membrane; mitochondrial outer membrane; membrane; mitochondrion;
Biological process	catecholamine metabolic process; dopamine catabolic process; neurotransmitter catabolic process; cellular biogenic amine metabolic process; neurotransmitter metabolic process; cytokine-mediated signaling pathway; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4128
	17161
	ENSG00000189221
	ENSMUSG00000025037
	P21397
	Q64133
	NM_001270458; NM_000240
	NM_173740
	NP_000231; NP_001257387
	NP_776101
	Wikidata
View/Edit Human	View/Edit Mouse

Monoamine oxidase A, also known as MAO-A, is an enzyme (E.C. 1.4.3.4) that in humans is encoded by the MAOA gene.^[5]^[6] This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as norepinephrine, serotonin and tyramine. A mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000189221 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025037 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hotamisligil GS, Breakefield XO (August 1991). "Human monoamine oxidase A gene determines levels of enzyme activity". American Journal of Human Genetics. 49 (2): 383–92. PMC 1683299. PMID 1678250.
^ Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC (May 1991). "Human monoamine oxidase A and B genes exhibit identical exon-intron organization". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3637–41. Bibcode:1991PNAS...88.3637G. doi:10.1073/pnas.88.9.3637. PMC 51507. PMID 2023912.
^ "Entrez Gene: MAOA monoamine oxidase A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000189221 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025037 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1678250-5] Hotamisligil GS, Breakefield XO (August 1991). "Human monoamine oxidase A gene determines levels of enzyme activity". American Journal of Human Genetics. 49 (2): 383–92. PMC 1683299. PMID 1678250.

[pmid2023912-6] Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC (May 1991). "Human monoamine oxidase A and B genes exhibit identical exon-intron organization". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3637–41. Bibcode:1991PNAS...88.3637G. doi:10.1073/pnas.88.9.3637. PMC 51507. PMID 2023912.

[entrez-7] "Entrez Gene: MAOA monoamine oxidase A".

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