Mucin-16

MUC16
Identifiers
Aliases	MUC16, CA125, mucin 16, cell surface associated
External IDs	OMIM: 606154; HomoloGene: 133291; GeneCards: MUC16; OMA:MUC16 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	8,981,342 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; epithelium of bronchus; ; olfactory zone of nasal mucosa; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; palpebral conjunctiva; ; trachea; ; epithelium of nasopharynx; ; right uterine tube; ; minor salivary glands;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi lumen; integral component of membrane; extracellular region; vesicle; extracellular exosome; membrane; extrinsic component of membrane; extracellular space; plasma membrane;
Biological process	cell adhesion; O-glycan processing; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	94025
	n/a
	ENSG00000181143
	n/a
	Q8WXI7
	n/a
	NM_024690; NM_001401501
	n/a
	NP_078966
	n/a
	Wikidata
View/Edit Human

Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the MUC16 gene.^[3]^[4]^[5] MUC-16 is a member of the mucin family glycoproteins.^[6] MUC-16 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, most notably ovarian cancer, or other conditions that are benign.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181143 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "MUC16 - Mucin-16 - Homo sapiens (Human) - MUC16 gene & protein". www.uniprot.org. Retrieved 15 June 2022.
^ Yin BW, Lloyd KO (Jul 2001). "Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16". The Journal of Biological Chemistry. 276 (29): 27371–5. doi:10.1074/jbc.M103554200. PMID 11369781.
^ Yin BW, Dnistrian A, Lloyd KO (Apr 2002). "Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene". International Journal of Cancer. 98 (5): 737–40. doi:10.1002/ijc.10250. PMID 11920644. S2CID 39365316.
^ Duraisamy S, Ramasamy S, Kharbanda S, Kufe D (May 2006). "Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16". Gene. 373: 28–34. doi:10.1016/j.gene.2005.12.021. PMID 16500040.
^ "CA 125 test". Mayo Clinic. Retrieved 3 January 2022.
^ Bast RC, Xu FJ, Yu YH, Barnhill S, Zhang Z, Mills GB (1998). "CA 125: the past and the future". The International Journal of Biological Markers. 13 (4): 179–87. doi:10.1177/172460089801300402. PMID 10228898. S2CID 46589946.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181143 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-3] "MUC16 - Mucin-16 - Homo sapiens (Human) - MUC16 gene & protein". www.uniprot.org. Retrieved 15 June 2022.

[pmid11369781-4] Yin BW, Lloyd KO (Jul 2001). "Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16". The Journal of Biological Chemistry. 276 (29): 27371–5. doi:10.1074/jbc.M103554200. PMID 11369781.

[pmid11920644-5] Yin BW, Dnistrian A, Lloyd KO (Apr 2002). "Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene". International Journal of Cancer. 98 (5): 737–40. doi:10.1002/ijc.10250. PMID 11920644. S2CID 39365316.

[pmid16500040-6] Duraisamy S, Ramasamy S, Kharbanda S, Kufe D (May 2006). "Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16". Gene. 373: 28–34. doi:10.1016/j.gene.2005.12.021. PMID 16500040.

[7] "CA 125 test". Mayo Clinic. Retrieved 3 January 2022.

[pmid10228898-8] Bast RC, Xu FJ, Yu YH, Barnhill S, Zhang Z, Mills GB (1998). "CA 125: the past and the future". The International Journal of Biological Markers. 13 (4): 179–87. doi:10.1177/172460089801300402. PMID 10228898. S2CID 46589946.

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