| MPO |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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1CXP, 1D2V, 1D5L, 1D7W, 1DNU, 1DNW, 1MHL, 1MYP, 3F9P, 3ZS0, 3ZS1, 4DL1, 4EJX, 4C1M, 5FIW |
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| Identifiers |
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| Aliases | MPO, myeloperoxidase |
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| External IDs | OMIM: 606989; MGI: 97137; HomoloGene: 55450; GeneCards: MPO; OMA:MPO - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 11 (mouse)[2] |
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| | Band | 11 52.22 cM|11 C | Start | 87,684,407 bp[2] |
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| End | 87,695,239 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - trabecular bone
- bone marrow cell
- monocyte
- olfactory zone of nasal mucosa
- gonad
- granulocyte
- testicle
- spleen
- amniotic fluid
- blood
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| | Top expressed in | - tibiofemoral joint
- fetal liver hematopoietic progenitor cell
- granulocyte
- body of femur
- ankle joint
- bone marrow
- human fetus
- vestibular membrane of cochlear duct
- spleen
- yolk sac
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | | | Cellular component | | | Biological process | | | Sources:Amigo / QuickGO |
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| Wikidata |
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Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17.[5] MPO is most abundantly expressed in neutrophils (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach.[5][6] It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation.[7] Neutrophil myeloperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as mucus and sputum.[8] The green color contributed to its outdated name verdoperoxidase.
Myeloperoxidase is found in many different organisms including mammals, birds, fish, reptiles, and amphibians. Myeloperoxidase deficiency is a well-documented disease among humans resulting in impaired immune function.[9]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000005381 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009350 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Myeloperoxidase".
- ^ Klebanoff SJ (May 2005). "Myeloperoxidase: friend and foe". Journal of Leukocyte Biology. 77 (5): 598–625. doi:10.1189/jlb.1204697. PMID 15689384. S2CID 12489688.
- ^ Kinkade JM, Pember SO, Barnes KC, Shapira R, Spitznagel JK, Martin LE (Jul 1983). "Differential distribution of distinct forms of myeloperoxidase in different azurophilic granule subpopulations from human neutrophils". Biochemical and Biophysical Research Communications. 114 (1): 296–303. Bibcode:1983BBRC..114..296K. doi:10.1016/0006-291x(83)91627-3. PMID 6192815.
- ^ Le T, Bhushan V, Sochat M, Damisch K, Abrams J, Kallianos K, et al. (2021). First Aid for the USMLE Step 1 (2021 ed.). New York: McGraw Hill. p. 109. ISBN 978-1-260-46752-9.
- ^ Cite error: The named reference
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