PTPRC

PTPRC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YGU, 1YGR, 5FMV, 5FN6, 5FN7
Identifiers
Aliases	PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
External IDs	OMIM: 151460; MGI: 97810; HomoloGene: 2126; GeneCards: PTPRC; OMA:PTPRC - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	198,757,476 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	138,103,446 bp
RNA expression pattern
	Top expressed in
	monocyte; ; appendix; ; blood; ; epithelium of nasopharynx; ; granulocyte; ; lymph node; ; bone marrow; ; bone marrow cell; ; thymus; ; spleen;
	Top expressed in
	granulocyte; ; spleen; ; thymus; ; tibiofemoral joint; ; stroma of bone marrow; ; submandibular gland; ; blood; ; right lung; ; Paneth cell; ; mesenteric lymph nodes;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein kinase binding; hydrolase activity; protein tyrosine phosphatase activity;
Cellular component	integral component of membrane; membrane; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; membrane raft; extracellular exosome; external side of plasma membrane; secretory granule membrane;
Biological process	B cell receptor signaling pathway; cell cycle phase transition; release of sequestered calcium ion into cytosol; negative regulation of protein kinase activity; bone marrow development; stem cell development; protein dephosphorylation; negative regulation of cytokine-mediated signaling pathway; positive regulation of hematopoietic stem cell migration; regulation of cell cycle; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of T cell mediated cytotoxicity; cell surface receptor signaling pathway; B cell proliferation; T cell differentiation; positive regulation of B cell proliferation; defense response to virus; positive regulation of T cell proliferation; hematopoietic progenitor cell differentiation; positive regulation of antigen receptor-mediated signaling pathway; T cell receptor signaling pathway; positive regulation of stem cell proliferation; dephosphorylation; positive regulation of protein kinase activity; peptidyl-tyrosine dephosphorylation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	5788
	19264
	ENSG00000081237; ENSG00000262418
	ENSMUSG00000026395
	P08575
	P06800
	NM_001267798; NM_002838; NM_080921; NM_080922
	NM_001111316; NM_001268286; NM_011210
	NP_001254727; NP_002829; NP_563578; NP_563578.2; NP_002829.3
	NP_001104786; NP_001255215; NP_035340
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene.^[5] PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA).^[6]

PTPRC is a critical enzyme involved in regulating immune cell function. PTPRC is a transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated hematopoietic cells, particularly lymphocytes. It plays a key role in the activation and differentiation of T cells, B cells, and other immune cells by modulating signaling pathways. It functions by dephosphorylating specific tyrosine residues on target proteins, thereby controlling various signaling processes essential for immune response and homeostasis.^[7]^[8]

^ ^a ^b ^c ENSG00000262418 GRCh38: Ensembl release 89: ENSG00000081237, ENSG00000262418 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026395 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, et al. (September 1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proceedings of the National Academy of Sciences of the United States of America. 87 (18): 7000–7004. Bibcode:1990PNAS...87.7000K. doi:10.1073/pnas.87.18.7000. PMC 54670. PMID 2169617.
^ "Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C".
^ Cite error: The named reference pmid12414720 was invoked but never defined (see the help page).
^ Thomas ML (1989). "The leukocyte common antigen family". Annual Review of Immunology. 7: 339–69. doi:10.1146/annurev.iy.07.040189.002011. PMID 2523715.

[refGRCh38Ensembl-1] ENSG00000262418 GRCh38: Ensembl release 89: ENSG00000081237, ENSG00000262418 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026395 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2169617-5] Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, et al. (September 1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proceedings of the National Academy of Sciences of the United States of America. 87 (18): 7000–7004. Bibcode:1990PNAS...87.7000K. doi:10.1073/pnas.87.18.7000. PMC 54670. PMID 2169617.

[entrez-6] "Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C".

[pmid12414720-7] Cite error: The named reference pmid12414720 was invoked but never defined (see the help page).

[pmid2523715-8] Thomas ML (1989). "The leukocyte common antigen family". Annual Review of Immunology. 7: 339–69. doi:10.1146/annurev.iy.07.040189.002011. PMID 2523715.

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