Proopiomelanocortin

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Opioids neuropeptide
Opioids neuropeptide
Identifiers
Symbol	Op_neuropeptide
Pfam	PF08035
InterPro	IPR013532
PROSITE	PDOC00964
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

POMC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LWC, 5E33, 1PLW, 1PLX
Identifiers
Aliases	POMC, POC, proopiomelanocortin, OBAIRH, LPH, CLIP, ACTH, NPP, MSH
External IDs	OMIM: 176830; MGI: 97742; HomoloGene: 723; GeneCards: POMC; OMA:POMC - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	25,168,903 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	4,010,642 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right testis; ; left testis; ; gonad; ; body of pancreas; ; right adrenal cortex; ; left adrenal gland; ; apex of heart; ; left adrenal cortex; ; right auricle of heart;
	Top expressed in
	pituitary gland; ; arcuate nucleus; ; median eminence; ; pars distalis of adenohypophysis; ; pars intermedia; ; ventromedial nucleus; ; suprachiasmatic nucleus; ; trophoblast giant cell; ; seminiferous tubule; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	type 3 melanocortin receptor binding; hormone activity; type 1 melanocortin receptor binding; signaling receptor binding; G protein-coupled receptor binding; type 4 melanocortin receptor binding; neuropeptide hormone activity;
Cellular component	cytoplasm; peroxisome; extracellular region; peroxisomal matrix; secretory granule lumen; extracellular space; secretory granule;
Biological process	glucose homeostasis; cellular pigmentation; cell-cell signaling; generation of precursor metabolites and energy; regulation of glycogen metabolic process; regulation of blood pressure; negative regulation of tumor necrosis factor production; regulation of appetite; signal transduction; positive regulation of transcription by RNA polymerase II; neuropeptide signaling pathway; positive regulation of neutrophil mediated killing of fungus; regulation of corticosterone secretion; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5443
	18976
	ENSG00000115138
	ENSMUSG00000020660
	P01189
	P01193
	NM_000939; NM_001035256; NM_001319204; NM_001319205
	NM_008895; NM_001278581; NM_001278582; NM_001278583; NM_001278584
	NP_000930; NP_001030333; NP_001306133; NP_001306134
	NP_001265510; NP_001265511; NP_001265512; NP_001265513; NP_032921
	Wikidata
View/Edit Human	View/Edit Mouse

Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation.^[5] POMC is part of the central melanocortin system.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115138 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020660 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "pro-opiomelanocortin preproprotein [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 30 December 2020.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115138 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020660 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "pro-opiomelanocortin preproprotein [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 30 December 2020.

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