Protein S

PROS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z6C
Identifiers
Aliases	PROS1, PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6, protein S (alpha), protein S
External IDs	OMIM: 176880; MGI: 1095733; HomoloGene: 264; GeneCards: PROS1; OMA:PROS1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	93,980,003 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	62,749,709 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; bronchial epithelial cell; ; synovial joint; ; germinal epithelium; ; parietal pleura; ; pericardium; ; liver; ; visceral pleura; ; spinal ganglia; ; trigeminal ganglion;
	Top expressed in
	cumulus cell; ; decidua; ; stroma of bone marrow; ; aortic valve; ; endothelial cell of lymphatic vessel; ; gastrula; ; iris; ; calvaria; ; left lung lobe; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; endopeptidase inhibitor activity;
Cellular component	blood microparticle; endoplasmic reticulum membrane; Golgi membrane; plasma membrane; extracellular region; Golgi lumen; extracellular exosome; platelet alpha granule lumen; extracellular space;
Biological process	hemostasis; fibrinolysis; platelet degranulation; blood coagulation; endoplasmic reticulum to Golgi vesicle-mediated transport; signal peptide processing; peptidyl-glutamic acid carboxylation; regulation of complement activation; leukocyte migration; negative regulation of endopeptidase activity; negative regulation of blood coagulation;
	Sources:Amigo / QuickGO
Orthologs
	5627
	19128
	ENSG00000184500
	ENSMUSG00000022912
	P07225
	Q08761
	NM_000313; NM_001314077
	NM_011173
	NP_000304; NP_001301006
	NP_035303
	Wikidata
View/Edit Human	View/Edit Mouse

Protein S (also known as PROS) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by the PROS1 gene.^[5]^[6] Protein S plays a role in coagulation.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184500 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022912 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lundwall A, Dackowski W, Cohen E, Shaffer M, Mahr A, Dahlbäck B, et al. (September 1986). "Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation". Proceedings of the National Academy of Sciences of the United States of America. 83 (18): 6716–6720. Bibcode:1986PNAS...83.6716L. doi:10.1073/pnas.83.18.6716. PMC 386580. PMID 2944113.
^ Long GL, Marshall A, Gardner JC, Naylor SL (January 1988). "Genes for human vitamin K-dependent plasma proteins C and S are located on chromosomes 2 and 3, respectively". Somatic Cell and Molecular Genetics. 14 (1): 93–98. doi:10.1007/BF01535052. PMID 2829367. S2CID 31236887.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184500 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022912 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2944113-5] Lundwall A, Dackowski W, Cohen E, Shaffer M, Mahr A, Dahlbäck B, et al. (September 1986). "Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation". Proceedings of the National Academy of Sciences of the United States of America. 83 (18): 6716–6720. Bibcode:1986PNAS...83.6716L. doi:10.1073/pnas.83.18.6716. PMC 386580. PMID 2944113.

[pmid2829367-6] Long GL, Marshall A, Gardner JC, Naylor SL (January 1988). "Genes for human vitamin K-dependent plasma proteins C and S are located on chromosomes 2 and 3, respectively". Somatic Cell and Molecular Genetics. 14 (1): 93–98. doi:10.1007/BF01535052. PMID 2829367. S2CID 31236887.

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