Resistin

RETN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LV6
Identifiers
Aliases	RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1, resistin
External IDs	OMIM: 605565; MGI: 1888506; HomoloGene: 10703; GeneCards: RETN; OMA:RETN - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,670,455 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,710,110 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cell; ; monocyte; ; trabecular bone; ; granulocyte; ; right lung; ; upper lobe of left lung; ; blood; ; spleen; ; gastric mucosa;
	Top expressed in
	white adipose tissue; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; lactiferous gland; ; intercostal muscle; ; tunica media of zone of aorta; ; mesenteric lymph nodes; ; brown adipose tissue; ; ankle joint; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity;
Cellular component	extracellular exosome; nucleus; extracellular region; extracellular space; azurophil granule lumen; specific granule lumen;
Biological process	positive regulation of smooth muscle cell migration; response to insulin; positive regulation of progesterone secretion; response to mechanical stimulus; ageing; positive regulation of collagen metabolic process; fat cell differentiation; positive regulation of synaptic transmission; negative regulation of feeding behavior; positive regulation of smooth muscle cell proliferation; neutrophil degranulation; regulation of signaling receptor activity; biological process; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	56729
	57264
	ENSG00000104918
	ENSMUSG00000012705
	Q9HD89
	Q99P87
	NM_020415; NM_001193374; NM_001385725; NM_001385726; NM_001385727
	NM_001204959; NM_022984
	NP_001180303; NP_065148
	NP_001191888; NP_075360
	Wikidata
View/Edit Human	View/Edit Mouse

Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1), is a cysteine-rich peptide hormone that is derived from adipose tissue and, in humans, is encoded by the RETN gene.^[5]

In primates, pigs, and dogs, resistin is secreted primarily by immune and epithelial cells, whereas in rodents, it is mainly secreted by adipose tissue. The human resistin pre-peptide consists of 108 amino acid residues, while in mice and rats it is 114 amino acids in length; the molecular weight is approximately 12.5 kDa. Resistin is classified as an adipose-derived hormone (similar to a cytokine), and its physiological role has been widely debated, particularly regarding its involvement in obesity and type II diabetes mellitus (T2DM).^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104918 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000012705 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang H, Chu WS, Hemphill C, Elbein SC (June 2002). "Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians". The Journal of Clinical Endocrinology and Metabolism. 87 (6): 2520–2524. doi:10.1210/jcem.87.6.8528. PMID 12050208.
^ Lazar MA (October 2007). "Resistin- and Obesity-associated metabolic diseases". Hormone and Metabolic Research = Hormon- und Stoffwechselforschung = Hormones et Metabolisme. 39 (10): 710–716. doi:10.1055/s-2007-985897. PMID 17952831.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104918 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000012705 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Wang_2002-5] Wang H, Chu WS, Hemphill C, Elbein SC (June 2002). "Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians". The Journal of Clinical Endocrinology and Metabolism. 87 (6): 2520–2524. doi:10.1210/jcem.87.6.8528. PMID 12050208.

[Lazar_2007-6] Lazar MA (October 2007). "Resistin- and Obesity-associated metabolic diseases". Hormone and Metabolic Research = Hormon- und Stoffwechselforschung = Hormones et Metabolisme. 39 (10): 710–716. doi:10.1055/s-2007-985897. PMID 17952831.

[1]

[2]

[3]

[4]

[5]

[6]