Roridin E

Roridin E
Names
	IUPAC name (1R,3R,8R,12E,17R,18E,20Z,24R,25S,26S)-17-[(1R)-1-hydroxyethyl]-5,13,25-trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,12,18,20-tetraene-26,2'-oxirane]-11,22-dione
Identifiers
CAS Number	16891-85-3;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:214188;
ChEMBL	ChEMBL509175;
ChemSpider	10210055;
PubChem CID	44593339;
UNII	98826FBF79;
CompTox Dashboard (EPA)	DTXSID501034221 ;
	InChI Key: KEEQQEKLEZRLDS-FLGSVKSYSA-N; InChI=1S/C29H38O8/c1-18-9-11-28-16-34-26(32)14-19(2)10-12-33-21(20(3)30)7-5-6-8-25(31)37-22-15-24(36-23(28)13-18)29(17-35-29)27(22,28)4/h5-8,13-14,20-24,30H,9-12,15-17H2,1-4H3/b7-5+,8-6-,19-14+/t20-,21-,22-,23-,24-,27-,28-,29+/m1/s1;
	SMILES CC1=C[C@@H]2[C@@]3(CC1)COC(=O)/C=C(/CCO[C@H](/C=C/C=C\C(=O)O[C@H]4[C@]3([C@]5(CO5)[C@@H](C4)O2)C)[C@@H](C)O)\C;
Properties
Chemical formula	C29H38O8
Molar mass	514.6
Appearance	White solid
Hazards
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	2 mg/kg (Mouse, injection)
Related compounds
Related compounds	Verrucarin A
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Roridin E is a mycotoxin of the trichothecene group. In nature it is mainly found in fungi of the Fusarium and Myrothecium species. The Fusarium and Myrothecium species belong to the most prevalent mycotoxin producing species in south-east Asia and Australia, therefore making them a considerable risk for the food crop production industry.^[1]

The fungi are abundant in various agricultural products (cereal crops) and their further processed products such as bread. The Fusarium and Myrothecium species invade and grow on crops, and may produce roridin E under moist and cool conditions.^[2]

In rats, the symptoms observed after exposure to roridin E and linoleic acid are increased blood glucose levels and a decrease in glutathione. This may attribute to the toxic effect of roridin E due to its ability to delay the absorption and elimination of the mycotoxin.^[3]

^ Turner, Nicholas W.; Subrahmanyam, Sreenath; Piletsky, Sergey A. (January 2009). "Analytical methods for determination of mycotoxins: A review". Analytica Chimica Acta. 632 (2): 168–180. Bibcode:2009AcAC..632..168T. doi:10.1016/j.aca.2008.11.010. PMID 19110091.
^ "Nivalenol in food and feed | EFSA". www.efsa.europa.eu. 2013-06-19. doi:10.2903/j.efsa.2013.3262. Retrieved 2025-03-16.
^ Omar, Hossam El-Din M.; El Sawi, Nagwa M.; Meki, Abdel-Raheim M.A. (December 1997). "Acute Toxicity of the Mycotoxin Roridin E on Liver and Kidney of Rats". Journal of Applied Animal Research. 12 (2): 145–152. doi:10.1080/09712119.1997.9706200. ISSN 0971-2119.

[1] Turner, Nicholas W.; Subrahmanyam, Sreenath; Piletsky, Sergey A. (January 2009). "Analytical methods for determination of mycotoxins: A review". Analytica Chimica Acta. 632 (2): 168–180. Bibcode:2009AcAC..632..168T. doi:10.1016/j.aca.2008.11.010. PMID 19110091.

[2] "Nivalenol in food and feed | EFSA". www.efsa.europa.eu. 2013-06-19. doi:10.2903/j.efsa.2013.3262. Retrieved 2025-03-16.

[3] Omar, Hossam El-Din M.; El Sawi, Nagwa M.; Meki, Abdel-Raheim M.A. (December 1997). "Acute Toxicity of the Mycotoxin Roridin E on Liver and Kidney of Rats". Journal of Applied Animal Research. 12 (2): 145–152. doi:10.1080/09712119.1997.9706200. ISSN 0971-2119.

[1]

[2]

[3]