Septate junction

Septate junctions are intercellular junctions found in invertebrate epithelial cells, appearing as ladder-like structures under electron microscopy. They are thought to provide structural strength and a barrier to solute diffusion through the intercellular space. They are considered somewhat analogous to the (vertebrate) tight junctions; however, tight and septate junctions are different in many ways. Known insect homologues of tight junction components are components of conserved signalling pathways that localize to either adherens junctions, the subapical complex, or the marginal zone.[1] Recent studies show that septate junctions are also identified in the myelinated nerve fibers of the vertebrates.[2][3]

  1. ^ Matter K, Balda MS (March 2003). "Signalling to and from tight junctions". Nature Reviews. Molecular Cell Biology. 4 (3): 225–36. doi:10.1038/nrm1055. PMID 12612641. S2CID 33852309.
  2. ^ Faivre-Sarrailh C, Banerjee S, Li J, Hortsch M, Laval M, Bhat MA (October 2004). "Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function". Development. 131 (20): 4931–42. doi:10.1242/dev.01372. PMID 15459097.
  3. ^ Genova JL, Fehon RG (June 2003). "Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila". The Journal of Cell Biology. 161 (5): 979–89. doi:10.1083/jcb.200212054. PMC 2172966. PMID 12782686.
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