Serum amyloid P component

APCS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV
Identifiers
Aliases	APCS, HEL-S-92n, PTX2, SAP, amyloid P component, serum
External IDs	OMIM: 104770; MGI: 98229; HomoloGene: 123932; GeneCards: APCS; OMA:APCS - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	159,588,865 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,722,608 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gallbladder; ; islet of Langerhans; ; pancreatic ductal cell; ; body of pancreas; ; skin of thigh; ; human kidney; ; cervix; ; ectocervix; ; Descending thoracic aorta;
	Top expressed in
	left lobe of liver; ; sexually immature organism; ; right kidney; ; epithelium of small intestine; ; human fetus; ; migratory enteric neural crest cell; ; ureter; ; atrioventricular junction; ; thoracic diaphragm; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; unfolded protein binding; metal ion binding; virion binding; complement component C1q complex binding; carbohydrate binding; identical protein binding; low-density lipoprotein particle binding;
Cellular component	blood microparticle; extracellular matrix; extracellular exosome; nucleus; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	negative regulation of monocyte differentiation; negative regulation of acute inflammatory response; negative regulation of viral entry into host cell; chaperone-mediated protein complex assembly; negative regulation of viral process; negative regulation of glycoprotein metabolic process; protein folding; acute-phase response; negative regulation of exo-alpha-sialidase activity; negative regulation of wound healing; innate immune response; complement activation, classical pathway;
	Sources:Amigo / QuickGO
Orthologs
	325
	20219
	ENSG00000132703
	ENSMUSG00000026542
	P02743
	P12246
	NM_001639
	NM_011318
	NP_001630
	NP_035448
	Wikidata
View/Edit Human	View/Edit Mouse

The serum amyloid P component (SAP) is the identical serum form of the amyloid P component (AP), a 25 kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid".^[5] APCS is its human gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132703 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026542 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cathcart ES; Shirahama T; Cohen AS (1967). "Isolation and identification of a plasma component of amyloid". Biochim. Biophys. Acta. 147 (2): 392–393. doi:10.1016/0005-2795(67)90420-5.
^ "Entrez Gene: APCS amyloid P component, serum".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132703 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026542 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Cathcart_1967-5] Cathcart ES; Shirahama T; Cohen AS (1967). "Isolation and identification of a plasma component of amyloid". Biochim. Biophys. Acta. 147 (2): 392–393. doi:10.1016/0005-2795(67)90420-5.

[entrez-6] "Entrez Gene: APCS amyloid P component, serum".

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