SOX2

SOX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O4X, 2LE4
Identifiers
Aliases	SOX2, ANOP3, MCOPS3, SRY-box 2, Sox2, SRY-box transcription factor 2
External IDs	OMIM: 184429; MGI: 98364; HomoloGene: 68298; GeneCards: SOX2; OMA:SOX2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	181,714,436 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	34,706,610 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; bronchial epithelial cell; ; ganglionic eminence; ; external globus pallidus; ; pars reticulata; ; dorsal motor nucleus of vagus nerve; ; ventral tegmental area; ; superior vestibular nucleus; ; oral cavity; ; subthalamic nucleus;
	Top expressed in
	medial ganglionic eminence; ; tooth germ; ; enamel organ; ; Rostral migratory stream; ; suprachiasmatic nucleus; ; vestibular sensory epithelium; ; ventricular zone; ; lateral septal nucleus; ; superior surface of tongue; ; median eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; miRNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription cis-regulatory region binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; transcription regulator complex; nucleoplasm; nucleus;
Biological process	eye development; pituitary gland development; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; somatic stem cell population maintenance; endodermal cell fate specification; positive regulation of cell-cell adhesion; tissue regeneration; negative regulation of transcription by RNA polymerase II; chromatin organization; transcription by RNA polymerase II; regulation of cysteine-type endopeptidase activity involved in apoptotic process; adenohypophysis development; transcription, DNA-templated; neuronal stem cell population maintenance; positive regulation of transcription, DNA-templated; multicellular organism development; glial cell fate commitment; response to wounding; osteoblast differentiation; positive regulation of cell differentiation; negative regulation of epithelial cell proliferation; regulation of gene expression; inner ear development; forebrain development; response to growth factor; negative regulation of canonical Wnt signaling pathway; positive regulation of MAPK cascade; positive regulation of transcription by RNA polymerase II; cytokine-mediated signaling pathway; cell differentiation; cell fate commitment; central nervous system development; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6657
	20674
	ENSG00000181449
	ENSMUSG00000074637
	P48431
	P48432
	NM_003106
	NM_011443
	NP_003097
	NP_035573
	Wikidata
View/Edit Human	View/Edit Mouse

SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.^[5]

Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids.^[5]

Sox2 holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181449 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074637 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "SOX2". NCBI.
^ Rizzino A (2009). "Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells". Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 1 (2): 228–236. doi:10.1002/wsbm.12. PMC 2794141. PMID 20016762.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181449 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074637 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] "SOX2". NCBI.

[pmid20016762-6] Rizzino A (2009). "Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells". Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 1 (2): 228–236. doi:10.1002/wsbm.12. PMC 2794141. PMID 20016762.

[1]

[2]

[3]

[4]

[5]

[6]