Thrombomodulin

THBD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS
Identifiers
Aliases	THBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, BDCA-3
External IDs	OMIM: 188040; MGI: 98736; HomoloGene: 308; GeneCards: THBD; OMA:THBD - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	23,049,672 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	148,250,108 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; vena cava; ; right lung; ; skin of hip; ; skin of abdomen; ; skin of thigh; ; periodontal fiber; ; lower lobe of lung; ; upper lobe of left lung; ; left coronary artery;
	Top expressed in
	right lung lobe; ; left lung; ; left lung lobe; ; calvaria; ; Gonadal ridge; ; ankle; ; aortic valve; ; ascending aorta; ; white adipose tissue; ; decidua;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; transmembrane signaling receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; integral component of plasma membrane; membrane; apicolateral plasma membrane; vacuolar membrane; extracellular space;
Biological process	hemostasis; female pregnancy; negative regulation of platelet activation; response to lipopolysaccharide; response to cAMP; negative regulation of fibrinolysis; blood coagulation; response to X-ray; signal transduction; negative regulation of blood coagulation; leukocyte migration;
	Sources:Amigo / QuickGO
Orthologs
	7056
	21824
	ENSG00000178726
	ENSMUSG00000074743
	P07204
	P15306
	NM_000361
	NM_009378
	NP_000352
	NP_033404
	Wikidata
View/Edit Human	View/Edit Mouse

Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme.^[5] Thrombomodulin is also expressed on human mesothelial cell,^[6] monocyte and a dendritic cell subset.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178726 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074743 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ IPR001491 Thrombomodulin Accessed January 19, 2012.
^ Verhagen HJ, Heijnen-Snyder GJ, Pronk A, Vroom TM, van Vroonhoven TJ, Eikelboom BC, et al. (December 1996). "Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts". British Journal of Haematology. 95 (3): 542–549. doi:10.1046/j.1365-2141.1996.d01-1935.x. PMID 8943899. S2CID 8417511.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178726 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074743 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] IPR001491 Thrombomodulin Accessed January 19, 2012.

[6] Verhagen HJ, Heijnen-Snyder GJ, Pronk A, Vroom TM, van Vroonhoven TJ, Eikelboom BC, et al. (December 1996). "Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts". British Journal of Haematology. 95 (3): 542–549. doi:10.1046/j.1365-2141.1996.d01-1935.x. PMID 8943899. S2CID 8417511.

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