Tiapride

Tiapride
Clinical data
Trade names	Tiapridal
Routes of; administration	Oral (tablets), IM, IV
ATC code	N05AL03 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	~75% (oral) (Tmax = 1 hour)
Protein binding	Negligible
Elimination half-life	2.9–3.6 hours
Excretion	Urine (70% as unchanged tiapride)
Identifiers
	IUPAC name N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide;
CAS Number	51012-32-9 ;
PubChem CID	5467;
ChemSpider	5268 ;
UNII	LAH70H9JPH;
KEGG	D08590 ;
ChEMBL	ChEMBL84158 ;
CompTox Dashboard (EPA)	DTXSID0023664 ;
ECHA InfoCard	100.051.717
Chemical and physical data
Formula	C15H24N2O4S
Molar mass	328.43 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)CCNC(=O)C1=C(C=CC(=C1)S(=O)(=O)C)OC;
	(verify)

Tiapride is a drug that selectively blocks D₂ and D₃ dopamine receptors in the brain. It is used to treat a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly.^[2] A derivative of benzamide, tiapride is chemically and functionally similar to other benzamide antipsychotics such as sulpiride and amisulpride known for their dopamine antagonist effects.

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Scatton B, Cohen C, Perrault G, Oblin A, Claustre Y, Schoemaker H, et al. (January 2001). "The preclinical pharmacologic profile of tiapride". European Psychiatry. 16 (Suppl 1): 29s – 34s. doi:10.1016/s0924-9338(00)00526-5. PMID 11520476. S2CID 22686596.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[scatton-2] Scatton B, Cohen C, Perrault G, Oblin A, Claustre Y, Schoemaker H, et al. (January 2001). "The preclinical pharmacologic profile of tiapride". European Psychiatry. 16 (Suppl 1): 29s – 34s. doi:10.1016/s0924-9338(00)00526-5. PMID 11520476. S2CID 22686596.

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