Vesicular monoamine transporter 1

SLC18A1
Identifiers
Aliases	SLC18A1, CGAT, VAT1, VMAT1, Vesicular monoamine transporter 1, solute carrier family 18 member A1, VMAT2
External IDs	OMIM: 193002; MGI: 106684; HomoloGene: 20664; GeneCards: SLC18A1; OMA:SLC18A1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	20,183,206 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	69,541,887 bp
RNA expression pattern
	Top expressed in
	testicle; ; rectum; ; monocyte; ; granulocyte; ; mucosa of sigmoid colon; ; right adrenal gland; ; mucosa of transverse colon; ; appendix; ; substantia nigra; ; duodenum;
	Top expressed in
	right kidney; ; convoluted tubule; ; proximal convoluted tubule; ; interventricular septum; ; human kidney; ; proximal straight tubule; ; gastrula; ; adrenal gland; ; stellate ganglion; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	monoamine transmembrane transporter activity; xenobiotic transmembrane transporter activity; serotonin:sodium symporter activity;
Cellular component	integral component of membrane; clathrin-sculpted monoamine transport vesicle membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; cytoplasmic vesicle membrane; cytoplasmic vesicle; integral component of plasma membrane; cell junction; synaptic vesicle membrane; synapse; terminal bouton;
Biological process	xenobiotic transmembrane transport; monoamine transport; neurotransmitter transport; aminergic neurotransmitter loading into synaptic vesicle; serotonin transport; transmembrane transport; serotonin uptake; xenobiotic transport;
	Sources:Amigo / QuickGO
Orthologs
	6570
	110877
	ENSG00000036565
	ENSMUSG00000036330
	P54219
	Q8R090
	NM_001135691; NM_001142324; NM_001142325; NM_003053
	NM_153054
	NP_001129163; NP_001135796; NP_001135797; NP_003044
	NP_694694
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicular monoamine transporter 1 (VMAT1), also known as chromaffin granule amine transporter (CGAT) or solute carrier family 18 member 1 (SLC18A1), is a protein that in humans is encoded by the SLC18A1 gene. VMAT1 is an integral membrane protein, which is embedded in synaptic vesicles and serves to transfer monoamines, such as norepinephrine, epinephrine, dopamine, and serotonin, between the cytosol and synaptic vesicles.^[5] SLC18A1 is an isoform of the vesicular monoamine transporter.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000036565 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eiden LE, Schäfer MK, Weihe E, Schütz B (February 2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch. 447 (5): 636–40. doi:10.1007/s00424-003-1100-5. PMID 12827358. S2CID 20764857.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000036565 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036330 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[discovery-5] Eiden LE, Schäfer MK, Weihe E, Schütz B (February 2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch. 447 (5): 636–40. doi:10.1007/s00424-003-1100-5. PMID 12827358. S2CID 20764857.

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