Alteplase
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| Trade names | Activase, Actilyse, Cathflo Activase, others |
| Other names | t-PA, rt-PA |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Intravenous |
| ATC code | |
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| Formula | C2569H3928N746O781S40 |
| Molar mass | 59042.52 g·mol−1 |
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Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter.[5] Alteplase is given by injection into a vein or artery.[5] Alteplase is the same as the normal human plasminogen activator produced in vascular endothelial cells[6] and is synthesized via recombinant DNA technology in Chinese hamster ovary cells (CHO). Alteplase causes the breakdown of a clot by inducing fibrinolysis.[7]
It is on the World Health Organization's List of Essential Medicines.[8]
- ^ Australian Public Assessment Report for Alteplase (AusPAR) (PDF). Therapeutic Goods Administration (TGA) (Report). February 2011.
- ^ Cite error: The named reference
Activase FDA labelwas invoked but never defined (see the help page). - ^ Cite error: The named reference
Cathflo Activase FDA labelwas invoked but never defined (see the help page). - ^ "Actilyse". European Medicines Agency. 17 September 2018. Archived from the original on 17 November 2020. Retrieved 14 November 2020.
- ^ a b "Alteplase Monograph for Professionals". Drugs.com. Archived from the original on 27 August 2020. Retrieved 11 November 2019.
- ^ Baskin JL, Pui CH, Reiss U, Wilimas JA, Metzger ML, Ribeiro RC, et al. (July 2009). "Management of occlusion and thrombosis associated with long-term indwelling central venous catheters". Lancet. 374 (9684): 159–69. doi:10.1016/S0140-6736(09)60220-8. PMC 2814365. PMID 19595350.
- ^ Cite error: The named reference
:6was invoked but never defined (see the help page). - ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.