Autism
| Autism | |
|---|---|
| Other names |
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Autism has many presentations, in-humans all around the world; From top left: an autistic toddler stacking cans; an autistic figure skater competitor; an autistic boy in Somalia playing the abacus; an autism activist Greta Thunberg, explicitly she stated that she had Asperger syndrome, which now considered as autism. | |
| Specialty | Psychiatry (neuropsychiatry), clinical psychology, pediatrics, occupational medicine |
| Symptoms | Difficulties in social interaction, verbal and nonverbal communication; inflexible routines; focused interests; repetitive body movements; unusual sensory responses |
| Complications | Social isolation, educational and employment problems, anxiety, stress, bullying, depression, self-harm, suicidality |
| Onset | Early childhood |
| Duration | Lifelong |
| Causes | Multifactorial, with many uncertain factors |
| Risk factors | Family history, certain genetic conditions, having older parents, certain prescribed drugs, perinatal and neonatal health issues |
| Diagnostic method | Based on combination of clinical observation of behavior and development and comprehensive diagnostic testing completed by a team of qualified professionals. For adults, the use of a patient's written and oral history of autistic traits becomes more important |
| Differential diagnosis | Attention deficit hyperactivity disorder, intellectual disability, language disorders, social (pragmatic) communication disorder, selective mutism, stereotypic movement disorder, Rett syndrome, anxiety disorders, obsessive–compulsive disorder, schizophrenia, personality disorders[1] |
| Management | Applied behavior analysis, cognitive behavioral therapy, occupational therapy, speech–language pathology |
| Frequency | One in 100 people (1%) worldwide[2][3] |
Autism, also known as autism spectrum disorder (ASD),[a] is a neurodevelopmental condition characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing differences, focused interests, and repetitive behaviors.[4] For a formal diagnosis, these characteristics must cause clinically significant challenges greater than what is typical for a person's age and culture and must affect several areas of daily life.[5][6][7][8] Motor coordination difficulties are common but not required. Because autism is a spectrum disorder, presentations vary and support needs range from minimal to 24-hour care, with some autistic people being non-speaking.[9][5][6][10]
Autism diagnoses have risen since the 1990s, largely because of broader diagnostic criteria, greater awareness and wider access to assessment.[2] Changing social demands may also play a role.[11][12] The World Health Organization estimates that about 1 in 100 children were diagnosed between 2012 and 2021 and notes the increasing trend.[b][2][3] Surveillance studies in community samples of adults suggest a similar share of the adult population would meet diagnostic criteria if formally assessed.[13] This rise has fueled anti-vaccine activists' disproven claim that vaccines cause autism,[14] based on a fraudulent 1998 study that was later retracted.[15] Autism is highly heritable and involves many genes, while environmental factors appear to have only a small, mainly prenatal role.[16][17][18] Boys are diagnosed several times more often than girls,[2][19] and conditions such as anxiety, depression, attention deficit hyperactivity disorder (ADHD), epilepsy, and intellectual disability are more common among autistic people.[20][21][22]
Autism is usually lifelong and there is no known cure.[23] Interventions such as applied behavior analysis (ABA), speech therapy, and occupational therapy can help increase self-care, social, and language skills,[24] though ABA has been criticized for emphasizing normalization.[25] Reducing environmental and social barriers helps autistic people participate more fully in education, employment, and other aspects of life.[26][27][28] Medications can help with some co-occurring problems.[29][30]
Autistic people are found in every demographic group and, with appropriate supports that promote independence and self-determination, can participate fully in their communities and lead meaningful, productive lives.[31][32] The idea of autism as a disorder has been challenged by the neurodiversity framework, which frames autistic traits as a healthy variation of the human condition.[33] This perspective, promoted by the autism rights movement, has gained research attention,[34] but remains a subject of debate and controversy among autistic people, advocacy groups, healthcare providers, and charities.[35][36]
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- ^ DSM-5-TR.
- ^ a b c d Zeidan J, Fombonne E, Scorah J, Ibrahim A, Durkin MS, Saxena S, Yusuf A, Shih A, Elsabbagh M (15 May 2022). "Global prevalence of autism: A systematic review update". Autism Research. 15 (5): 778–790. doi:10.1002/aur.2696. ISSN 1939-3806. PMC 9310578. PMID 35238171.
- ^ a b Cite error: The named reference
World Health Organization-2022was invoked but never defined (see the help page). - ^ Diagnostic and Statistical Manual of Mental Disorders (5th ed.). American Psychiatric Association. 2013. p. 31.
- ^ a b (World Health Organization: International Classification of Diseases version 11 (ICD-11)): https://icd.who.int/browse/2024-01/mms/en#437815624
- ^ a b "IACC Subcommittee Diagnostic Criteria - DSM-5 Planning Group". iacc.hhs.gov. Retrieved 1 August 2024.
- ^ Guidelines from the UK National Institute for Health & Care Excellence (NICE): https://www.nice.org.uk/guidance/cg170/resources/autism-spectrum-disorder-in-under-19s-support-and-management-pdf-35109745515205
- ^ Fuentes J, Hervás A, Howlin P, ESCAP ASD Working Party (2020). "ESCAP practice guidance for autism: a summary of evidence‑based recommendations for diagnosis and treatment" (PDF). European Child & Adolescent Psychiatry. 30 (6): 961–984. doi:10.1007/s00787-020-01587-4. PMC 8140956. PMID 32666205.
- ^ Zhuang H, Liang Z, Ma G, Qureshi A, Ran X, Feng C, Liu X, Yan X, Shen L (2024). "Autism spectrum disorder: Pathogenesis, biomarker, and intervention therapy". Medcomm. 5 (3) e497. doi:10.1002/mco2.497. PMC 10908366. PMID 38434761.
- ^ Waizbard-Bartov E, Fein D, Lord C, Amaral DG (2023). "Autism severity and its relationship to disability". Autism Research. 16 (4): 685–696. doi:10.1002/aur.2898. ISSN 1939-3806. PMC 10500663. PMID 36786314.
- ^ Anderson-Chavarria M (14 September 2022). "The autism predicament: models of autism and their impact on autistic identity". Disability & Society. 37 (8): 1321–1341. doi:10.1080/09687599.2021.1877117. ISSN 0968-7599.
- ^ Ogundele MO, Morton MJ (3 April 2025). "Subthreshold Autism and ADHD: A Brief Narrative Review for Frontline Clinicians". Pediatric Reports. 17 (2): 42. doi:10.3390/pediatric17020042. ISSN 2036-749X. PMC 12030661. PMID 40278522.
- ^ Hirota T, King BH (10 January 2023). "Autism Spectrum Disorder: A Review". JAMA. 329 (2): 157–168. doi:10.1001/jama.2022.23661. ISSN 1538-3598. PMID 36625807.
- ^ DeStefano F, Shimabukuro TT (September 2019). "The MMR Vaccine and Autism". Annual Review of Virology. 6 (1): 585–600. doi:10.1146/annurev-virology-092818-015515. PMC 6768751. PMID 30986133.
- ^ "General Medical Council, Fitness to Practise Panel Hearing, 24 May 2010, Andrew Wakefield, Determination of Serious Professional Misconduct" (PDF). General Medical Council. Archived from the original (PDF) on 9 August 2011. Retrieved 18 September 2011.
- ^ Hodges H, Fealko C, Soares N (February 2020). "Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation". Translational Pediatrics. 9 (Suppl 1): S55–S5S65. doi:10.21037/tp.2019.09.09. ISSN 2224-4344. PMC 7082249. PMID 32206584.
- ^ Ratajczak HV (1 March 2011). "Theoretical aspects of autism: Causes—A review". Journal of Immunotoxicology. 8 (1): 68–79. doi:10.3109/1547691X.2010.545086. ISSN 1547-691X. PMID 21299355.
- ^ Mandy W, Lai MC (March 2016). "Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition". Journal of Child Psychology and Psychiatry, and Allied Disciplines. 57 (3): 271–292. doi:10.1111/jcpp.12501. eISSN 1469-7610. ISSN 0021-9630. OCLC 01307942. PMID 26782158.
- ^ Cite error: The named reference
:14was invoked but never defined (see the help page). - ^ Bertelli MO, Azeem MW, Underwood L, Scattoni ML, Persico AM, Ricciardello A, Sappok T, Bergmann T, Keller R (2022), Bertelli MO, Deb S(, Munir K, Hassiotis A (eds.), "Autism Spectrum Disorder", Textbook of Psychiatry for Intellectual Disability and Autism Spectrum Disorder, Cham: Springer International Publishing, p. 391, doi:10.1007/978-3-319-95720-3_16, ISBN 978-3-319-95720-3, retrieved 8 June 2022,
Persons with autism spectrum disorder and/or other neurodevelopmental problems are more likely than the general population to have transgender identity, non-heterosexual sexual orientation, and other gender non-conformities.
- ^ Lord C, Charman T, Havdahl A, Carbone P, Anagnostou E, Boyd B, Carr T, de Vries PJ, Dissanayake C, Divan G, et al. (2022). "The Lancet Commission on the future of care and clinical research in autism" (PDF). The Lancet. 399 (10321): 299–300. doi:10.1016/s0140-6736(21)01541-5. hdl:11250/2975811. PMID 34883054. S2CID 244917920 – via Norwegian Institute of Public Health.
- ^ Graham Holmes L, Ames JL, Massolo ML, Nunez DM, Croen LA (1 April 2022). "Improving the Sexual and Reproductive Health and Health Care of Autistic People". Pediatrics. 149 (Supplement 4). American Academy of Pediatrics: e2020049437J. doi:10.1542/peds.2020-049437J. ISSN 0031-4005. PMID 35363286.
A substantial proportion of autistic adolescents and adults are LGBTQIA+. Autistic people are more likely to be transgender or gender nonconforming compared with non-autistic people, and findings from a recent autism registry study suggest that among autistic people able to self-report on a survey, up to 18% of men and 43% of women may be sexual minorities.
- ^ Steinhausen HC, Mohr Jensen C, Lauritsen MB (13 January 2016). "A systematic review and meta-analysis of the long-term overall outcome of autism spectrum disorders in adolescence and adulthood". Acta Psychiatrica Scandinavica. 133 (6): 445–452. doi:10.1111/acps.12559. ISSN 1600-0447. PMID 26763353.
- ^ CDC (18 July 2024). "Treatment and Intervention for Autism Spectrum Disorder". Autism Spectrum Disorder (ASD). Retrieved 28 November 2024.
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:7was invoked but never defined (see the help page). - ^ "Medication Treatment for Autism". National Institute of Child Health and Human Development. 19 April 2021. Archived from the original on 7 February 2023. Retrieved 21 February 2023.
- ^ Rzepka-Migut B, Paprocka J (2020). "Efficacy and Safety of Melatonin Treatment in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder—A Review of the Literature". Brain Sciences. 10 (4): 219. doi:10.3390/brainsci10040219. ISSN 2076-3425. PMC 7226342. PMID 32272607.
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:32was invoked but never defined (see the help page). - ^ Kapp, Steven K. Autistic community and the neurodiversity movement: Stories from the frontline. Springer Nature, 2020.
- ^ Happé F, Frith U (2020). "Annual Research Review: Looking back to look forward - changes in the concept of autism and implications for future research". Journal of Child Psychology and Psychiatry, and Allied Disciplines. 61 (3): 218–232. doi:10.1111/jcpp.13176. ISSN 1469-7610. PMID 31994188.
- ^ "Disorder or difference? Autism researchers face off over field's terminology". www.science.org. Retrieved 3 May 2025.
- ^ Rodríguez Mega E (10 May 2023). "'I am not a broken version of normal' — autistic people argue for a stronger voice in research". Nature. 617 (7960): 238–241. doi:10.1038/d41586-023-01549-1. PMID 37165246.