Calcitonin gene-related peptide

Calcitonin-related polypeptide, beta
Calcitonin-related polypeptide, beta
Identifiers
Symbol	CALCB
Alt. symbols	CALC2
NCBI gene	797
HGNC	1438
OMIM	114160
RefSeq	NM_000728
UniProt	P10092
Other data
Locus	Chr. 11 p15.2{{{LocusSupplementaryData}}}
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

Calcitonin-related polypeptide alpha
Calcitonin-related polypeptide alpha
	Human calcitonin (black) bound to the calcitonin receptor. PDB: 7TYO
Identifiers
Symbol	CALCA
Alt. symbols	CALC1
NCBI gene	796
HGNC	1437
OMIM	114130
RefSeq	NM_001741
UniProt	P06881
Other data
Locus	Chr. 11 p15.2{{{LocusSupplementaryData}}}
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Calcitonin gene-related peptide (CGRP) is a neuropeptide that belongs to the calcitonin family.^[1] Human CGRP consists of two isoforms, CGRP alpha (α-CGRP, also known as CGRP I) and CGRP beta (β-CGRP, also known as CGRP II).^[2] α-CGRP is a 37-amino acid neuropeptide formed by alternative splicing^[3] of the calcitonin/CGRP gene located on chromosome 11. β-CGRP is less studied. In humans, β-CGRP differs from α-CGRP by three amino acids and is encoded in a separate, nearby gene.^[4] The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY).^[5]

^ Russell, F. A.; King, R.; Smillie, S.-J.; Kodji, X.; Brain, S. D. (October 2014). "Calcitonin Gene-Related Peptide: Physiology and Pathophysiology". Physiological Reviews. 94 (4): 1099–1142. doi:10.1152/physrev.00034.2013. ISSN 0031-9333. PMC 4187032. PMID 25287861.
^ Russell FA, King R, Smillie SJ, Kodji X, Brain SD (October 2014). "Calcitonin gene-related peptide: physiology and pathophysiology". Physiological Reviews. 94 (4): 1099–142. doi:10.1152/physrev.00034.2013. PMC 4187032. PMID 25287861.
^ Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (July 1982). "Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products". Nature. 298 (5871): 240–4. Bibcode:1982Natur.298..240A. doi:10.1038/298240a0. PMID 6283379. S2CID 24188834.
^ Rezaeian AH, Isokane T, Nishibori M, Chiba M, Hiraiwa N, Yoshizawa M, Yasue H (October 2009). "alphaCGRP and betaCGRP transcript amount in mouse tissues of various developmental stages and their tissue expression sites". Brain & Development. 31 (9): 682–93. doi:10.1016/j.braindev.2008.10.011. PMID 19062206. S2CID 21635386.
^ Edvinsson L (May 2017). "The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine". Headache. 57 Suppl 2 (S2): 47–55. doi:10.1111/head.13081. PMID 28485848.

[1] Russell, F. A.; King, R.; Smillie, S.-J.; Kodji, X.; Brain, S. D. (October 2014). "Calcitonin Gene-Related Peptide: Physiology and Pathophysiology". Physiological Reviews. 94 (4): 1099–1142. doi:10.1152/physrev.00034.2013. ISSN 0031-9333. PMC 4187032. PMID 25287861.

[Calcitonin_gene-related_peptide:_ph-2] Russell FA, King R, Smillie SJ, Kodji X, Brain SD (October 2014). "Calcitonin gene-related peptide: physiology and pathophysiology". Physiological Reviews. 94 (4): 1099–142. doi:10.1152/physrev.00034.2013. PMC 4187032. PMID 25287861.

[3] Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (July 1982). "Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products". Nature. 298 (5871): 240–4. Bibcode:1982Natur.298..240A. doi:10.1038/298240a0. PMID 6283379. S2CID 24188834.

[pmid19062206-4] Rezaeian AH, Isokane T, Nishibori M, Chiba M, Hiraiwa N, Yoshizawa M, Yasue H (October 2009). "alphaCGRP and betaCGRP transcript amount in mouse tissues of various developmental stages and their tissue expression sites". Brain & Development. 31 (9): 682–93. doi:10.1016/j.braindev.2008.10.011. PMID 19062206. S2CID 21635386.

[5] Edvinsson L (May 2017). "The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine". Headache. 57 Suppl 2 (S2): 47–55. doi:10.1111/head.13081. PMID 28485848.

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