CD23

FCER2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N, 4J6P, 4J6Q
Identifiers
Aliases	FCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II
External IDs	OMIM: 151445; MGI: 95497; HomoloGene: 1517; GeneCards: FCER2; OMA:FCER2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,702,146 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,744,175 bp
RNA expression pattern
	Top expressed in
	testicle; ; granulocyte; ; spleen; ; lymph node; ; appendix; ; blood; ; monocyte; ; mucosa of transverse colon; ; bone marrow cell; ; tonsil;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; blood; ; subcutaneous adipose tissue; ; granulocyte; ; embryo; ; thymus; ; tibiofemoral joint; ; white adipose tissue; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	IgE binding; integrin binding; protein binding; metal ion binding; carbohydrate binding;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; extracellular exosome; external side of plasma membrane; membrane;
Biological process	Notch signaling pathway; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of nitric-oxide synthase activity; positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase biosynthetic process; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2208
	14128
	ENSG00000104921
	ENSMUSG00000005540
	P06734
	P20693
	NM_001207019; NM_001220500; NM_002002
NM_001253737; NM_001253739; NM_001253743; NM_001253745; NM_001253746;
	NM_001253747; NM_013517
	NP_001193948; NP_001207429; NP_001993
NP_001240666; NP_001240668; NP_001240672; NP_001240674; NP_001240675;
	NP_001240676; NP_038545
	Wikidata
View/Edit Human	View/Edit Mouse

CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.

There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104921 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005540 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lichtman AH, Abbas AK (2003). Cellular and molecular immunology. Philadelphia: Saunders. pp. 324–325. ISBN 0-7216-0008-5.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104921 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005540 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[isbn0-7216-0008-5-5] Lichtman AH, Abbas AK (2003). Cellular and molecular immunology. Philadelphia: Saunders. pp. 324–325. ISBN 0-7216-0008-5.

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