CD80

CD80
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DR9, 1I8L
Identifiers
Aliases	CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule
External IDs	OMIM: 112203; MGI: 101775; HomoloGene: 3804; GeneCards: CD80; OMA:CD80 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	119,559,614 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	38,316,697 bp
RNA expression pattern
	Top expressed in
	testicle; ; lower lobe of lung; ; pancreatic ductal cell; ; tibialis anterior muscle; ; appendix; ; lymph node; ; spleen; ; upper lobe of lung; ; upper lobe of left lung; ; mucosa of ileum;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; embryo; ; thymus; ; sternocleidomastoid muscle; ; spleen; ; vastus lateralis muscle; ; blood; ; endothelial cell of lymphatic vessel; ; major salivary gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	coreceptor activity; virus receptor activity; protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	membrane; cell surface; external side of plasma membrane; integral component of membrane; plasma membrane; intracellular anatomical structure; protein complex involved in cell adhesion;
Biological process	T cell costimulation; intracellular signal transduction; positive regulation of alpha-beta T cell proliferation; cell-cell signaling; positive regulation of signal transduction; cellular response to lipopolysaccharide; positive regulation of T-helper 1 cell differentiation; viral process; viral entry into host cell; positive regulation of T cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-templated; T cell activation; phosphatidylinositol phosphate biosynthetic process; positive regulation of protein kinase B signaling; immune response; signal transduction; cell surface receptor signaling pathway; cytokine-mediated signaling pathway; negative regulation of T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	941
	12519
	ENSG00000121594
	ENSMUSG00000075122
	P33681
	Q00609
	NM_005191
	NM_009855; NM_001359898
	NP_005182
	NP_033985; NP_001346827
	Wikidata
View/Edit Human	View/Edit Mouse

The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein^[5] in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121594 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000075122 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McKusick, V. A., & Converse, P. J. (2016, August 05). CD80 Antigen; CD80. Retrieved May 29, 2019
^ Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS (September 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". The Journal of Biological Chemistry. 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. PMID 7545666.
^ Cite error: The named reference :0 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121594 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000075122 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] McKusick, V. A., & Converse, P. J. (2016, August 05). CD80 Antigen; CD80. Retrieved May 29, 2019

[Peach_1995-6] Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS (September 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". The Journal of Biological Chemistry. 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. PMID 7545666.

[:0-7] Cite error: The named reference :0 was invoked but never defined (see the help page).

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