Ringer's lactate solution
A bottle of Ringer's lactate solution | |
| Clinical data | |
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| Other names | compound sodium lactate, sodium lactate solution, Hartmann's solution, Ringer-Locke's solution, Ringer-lactate, lactated Ringer's solution (LRS) |
| AHFS/Drugs.com | FDA Professional Drug Information |
| License data | |
| Routes of administration | intravenous, topical, subcutaneous |
| ATC code | |
Ringer's lactate solution (RL), also known as sodium lactate solution, Lactated Ringer's (LR), and Hartmann's solution, is a mixture of sodium chloride, sodium lactate, potassium chloride, and calcium chloride in water.[1] It is used for replacing fluids and electrolytes in those who have low blood volume or low blood pressure.[2] It may also be used to treat metabolic acidosis and to wash the eye following a chemical burn.[2][3] It is given by intravenous infusion or applied to the affected area.[2][3]
Side effects may include allergic reactions, high blood potassium, hypervolemia, and high blood calcium.[2] It may not be suitable for mixing with certain medications and some recommend against use in the same infusion as a blood transfusion.[4] Ringer's lactate solution has a lower rate of acidosis as compared with normal saline.[1][4] Use is generally safe in pregnancy and breastfeeding.[2] Ringer's lactate solution is in the crystalloid family of medications.[5] It is isotonic, i.e. it has the same tonicity as blood.[2]
Ringer's solution was invented in the 1880s; lactate was added in the 1930s.[4] It is on the World Health Organization's List of Essential Medicines.[6] Lactated Ringer's is available as a generic medication.[1] For people with liver dysfunction, Ringer's acetate may be a better alternative with the lactate replaced by acetate.[7] In Scandinavia Ringer's acetate is typically used.[8]
- ^ a b c British national formulary: BNF 69 (69 ed.). British Medical Association. 2015. p. 683. ISBN 9780857111562.
- ^ a b c d e f "Compound Sodium Lactate Solution for Infusion - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. February 2013. Archived from the original on 16 January 2017. Retrieved 14 January 2017.
- ^ a b Krieglstein GK (2000). Atlas of Ophthalmology. Springer Science & Business Media. p. 377. ISBN 9783540780694. Archived from the original on 16 January 2017.
- ^ a b c Marino PL, Sutin KM (2012). The ICU Book (3rd ed.). Lippincott Williams & Wilkins. p. 363. ISBN 9781451161557. Archived from the original on 18 September 2017.
- ^ Saade GR, Foley MR, Phelan III JP, Dildy GA (2010). Critical Care Obstetrics. John Wiley & Sons. p. 70. ISBN 9781444396140. Archived from the original on 16 January 2017.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ Marino PL (2013). Marino's The ICU Book (4 ed.). Lippincott Williams & Wilkins. p. 223. ISBN 9781469831640. Archived from the original on 16 January 2017.
- ^ Bjarby J. "Vätsketerapi för AT/ST läkare KSS — 'Rehydration therapy for interns and specialists, KSS'" (PDF). Västragötalandsregionen. Archived (PDF) from the original on 16 January 2017. Retrieved 13 January 2017.